Abstract
Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27(kip1). Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Cell Cycle
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Cyclin D1 / biosynthesis*
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Cyclin-Dependent Kinase Inhibitor p27 / metabolism
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Disease Progression
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Extracellular Signal-Regulated MAP Kinases / metabolism
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G1 Phase*
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Gene Expression Regulation, Neoplastic*
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Humans
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Integrins / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Signal Transduction
Substances
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Integrins
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Cyclin D1
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Cyclin-Dependent Kinase Inhibitor p27
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Phosphatidylinositol 3-Kinases
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Proto-Oncogene Proteins c-akt
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Extracellular Signal-Regulated MAP Kinases