Abstract
The Ras and Rho GTPases contribute to the initiation and progression of cancer by subverting the normal regulation of specific intracellular signalling pathways. As a result, Ras and Rho play significant roles in the development of numerous aspects of the malignant phenotype by promoting cell cycle progression, resistance to apoptotic stimuli, neo-vascularisation and tumour cell motility, invasiveness and metastasis. With these GTPases contributing at so many levels, they are appealing targets for the development of cancer chemotherapeutic agents.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Diphosphonates / pharmacology
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Endopeptidases / metabolism
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
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Neoplasms / drug therapy*
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Neoplasms / enzymology
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Protein Methyltransferases / antagonists & inhibitors
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Protein Processing, Post-Translational / physiology*
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ras Proteins / antagonists & inhibitors*
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rho GTP-Binding Proteins / antagonists & inhibitors*
Substances
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Diphosphonates
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Protein Methyltransferases
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protein-S-isoprenylcysteine O-methyltransferase
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Endopeptidases
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ras Proteins
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rho GTP-Binding Proteins