Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation

Eur J Pharmacol. 2004 Jun 16;493(1-3):99-102. doi: 10.1016/j.ejphar.2004.04.017.

Abstract

A poor supply of oxygen and glucose to the brain can cause severe brain damage. Therefore, neuroprotective drugs against ischemia need to be developed. In this study, wogonin, a flavone found in Scutellaria baicalensis, had a protective effect on neuronal cells damaged by oxygen and glucose deprivation in rat hippocampal slices in culture. In particular, the protective effect on the pyramidal cell layer was significant. On the basis of these experimental results, wogonin may be a therapeutic agent for treating ischemia in patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Death / physiology
  • Cell Hypoxia / drug effects
  • Cell Hypoxia / physiology
  • Drug Evaluation, Preclinical / methods
  • Flavanones / pharmacology*
  • Flavanones / therapeutic use
  • Forecasting
  • Glucose / adverse effects
  • Glucose / deficiency
  • Glucose / physiology
  • Korea
  • Neuroprotective Agents / pharmacology*
  • Pyramidal Cells / drug effects*
  • Pyramidal Cells / pathology*
  • Pyramidal Cells / ultrastructure
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
  • Tissue Culture Techniques / methods

Substances

  • Flavanones
  • Neuroprotective Agents
  • Glucose
  • wogonin