Abstract
Rhomboid proteases are integral membrane proteins, typically associated with cleavage of peptide hormones along the secretory pathway. Recent publications demonstrate that yeast mitochondria contain a rhomboid protease required for the cleavage of two mitochondrial intermembrane space proteins, suggesting that rhomboid proteases play a regulatory role in mitochondria.
MeSH terms
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Cytochrome-c Peroxidase / metabolism
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Endopeptidases / metabolism*
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GTP Phosphohydrolases / metabolism
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GTP-Binding Proteins / metabolism*
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Gene Deletion
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Membrane Proteins / metabolism*
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Mitochondrial Proteins / metabolism*
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Models, Biological
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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Saccharomyces cerevisiae Proteins / metabolism*
Substances
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MGM1 protein, S cerevisiae
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Membrane Proteins
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Mitochondrial Proteins
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Protein Isoforms
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Saccharomyces cerevisiae Proteins
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Cytochrome-c Peroxidase
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Endopeptidases
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GTP Phosphohydrolases
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GTP-Binding Proteins