Abstract
The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD(50) in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Amphetamine
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Animals
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Crinum*
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Dose-Response Relationship, Drug
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Female
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Hypnotics and Sedatives / administration & dosage
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Hypnotics and Sedatives / pharmacology*
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Hypnotics and Sedatives / therapeutic use
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Injections, Intraperitoneal
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Pentobarbital
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rats
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Rats, Wistar
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Sleep / drug effects
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Stereotyped Behavior / drug effects
Substances
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Hypnotics and Sedatives
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Plant Extracts
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Amphetamine
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Pentobarbital