Dynamic remodeling of transcription complexes by molecular chaperones

Cell. 2002 Aug 9;110(3):281-4. doi: 10.1016/s0092-8674(02)00860-7.

Abstract

The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.

Publication types

  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Gene Expression Regulation / physiology
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / metabolism*
  • Humans
  • Macromolecular Substances
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Protein Structure, Tertiary / genetics
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction / genetics
  • Stress, Physiological / metabolism*
  • Stress, Physiological / physiopathology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Heat-Shock Proteins
  • Macromolecular Substances
  • Molecular Chaperones
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors