Abstract
The AcrAB system of Escherichia coli is a multidrug efflux system composed of an RND-type transporter AcrB and a periplasmic accessory protein AcrA, and pumps out a wide variety of lipophilic and amphiphilic inhibitors directly into the medium, presumably through the TolC outer membrane channel. AcrA, a highly elongated protein, is thought to bring the outer and inner membranes closer. It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Bacterial Outer Membrane Proteins / chemistry
-
Bacterial Outer Membrane Proteins / metabolism
-
Bacterial Proteins / chemistry
-
Bacterial Proteins / metabolism*
-
Binding Sites
-
Carrier Proteins / metabolism
-
Drug Resistance, Microbial*
-
Drug Resistance, Multiple*
-
Escherichia coli / genetics
-
Escherichia coli / physiology*
-
Escherichia coli Proteins*
-
Lipoproteins / chemistry
-
Lipoproteins / metabolism*
-
Membrane Proteins / chemistry
-
Membrane Proteins / metabolism*
-
Membrane Transport Proteins
-
Models, Molecular
-
Multidrug Resistance-Associated Proteins
-
Protein Structure, Secondary
Substances
-
AcrA protein, E coli
-
AcrB protein, E coli
-
Bacterial Outer Membrane Proteins
-
Bacterial Proteins
-
Carrier Proteins
-
Escherichia coli Proteins
-
Lipoproteins
-
Membrane Proteins
-
Membrane Transport Proteins
-
Multidrug Resistance-Associated Proteins
-
tolC protein, E coli