Abstract
This paper describes the acute toxicity of two azulylamides and six azulenecarboxamides and the nerve conduction-inhibiting properties of some of these compounds. The azulene derivatives are compared to their benzenoid prototypes, lidocaine and procainamide, as part of a continuing investigation of the biological properties of nonbenzenoid aromatic compounds.
MeSH terms
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Acetamides / pharmacology
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Action Potentials / drug effects
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Amides / pharmacology*
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Amides / toxicity
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Anesthetics, Local*
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Animals
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Cycloheptanes / pharmacology*
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Cycloheptanes / toxicity
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Cyclopentanes / pharmacology
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Cyclopentanes / toxicity
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Dose-Response Relationship, Drug
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Electric Stimulation
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In Vitro Techniques
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Kinetics
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Lethal Dose 50
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Lidocaine / pharmacology
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Neural Conduction / drug effects
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Nitro Compounds / pharmacology
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Procainamide / pharmacology
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Rana pipiens
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Respiration / drug effects
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Sciatic Nerve / drug effects
Substances
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Acetamides
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Amides
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Anesthetics, Local
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Cycloheptanes
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Cyclopentanes
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Nitro Compounds
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Lidocaine
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Procainamide