Apoptosis is a form of cell death that takes place under physiologic conditions, and plays a key role in the control of biological processes such as embryonic development, tissue remodelation and renewal, or regulation of cell populations. Since its discovery in the early 1970s, there have been many relevant advances in the knowledge of the biochemical and molecular events involved in apoptosis. However, although the apoptotic process was defined on the basis of morphologic observations, only recently have we started to elucidate the molecular mechanisms that drive the structural changes observed in cells undergoing apoptosis. The article reviews current knowledge about the implications of cytoskeleton components (microfilaments, intermediate filaments, microtubules, and other cytoskeleton-related proteins) in the dynamics of apoptosis.