Affiliations: Hemorheology Center, Department of Biophysics, Peking University Health Science Center, Beijing, China | Chengde Medical College, Chengde, Hebei Province, China | Department of Cardiology, Peking University Shougang Hospital, Beijing, China
Note: [] Corresponding author: Dongqi He, Hemorheology Center, Department of Biophysics, Peking University Health Science Center, Beijing 100191, China. Tel.: +86 10 82802419; E-mail: [email protected] (Dongqi He)
Note: [] Corresponding author: Xifu Wang, Department of Cardiology, Peking University Shougang Hospital, Beijing 100144, China; E-mail: [email protected] (Xifu Wang)
Abstract: Dichlorvos is an important insecticide used largely. Some studies have demonstrated that organophosphate pesticide has effects on erythrocyte membrane structures, which is critical to erythrocyte function and hemorheology. The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. Data indicated that after dichlorvos exposure the hematocrit adjusted viscosity at high shear rate increased and erythrocyte membrane fluidity decreased. Data obtained from plasma showed that lipid peroxidative substance-malonaldehyde was elevated and superoxide dismutase was reduced. In summary, oxidative stress does occur in dichlorvos poisoning and may lead to hemorheological alterations. The changes of hemorheology may be responsible for the pathophysiology of the dichlorvos poisoning.
