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Hot Ortho-Biologic Topics at AAOS 2011

Platelet-Rich Plasma and Related Growth Factors Generate Excitement

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Abstract

Several hot topics relating to ortho-biologics were discussed at the 2011 Annual Meeting of the American Academy of Orthopedic Surgery (AAOS) in San Diego this February.

Injecting a patient’s own platelet-rich plasma (PRP) prior to orthopedic surgery was an important topic, and had its own forum devoted to debating its uses and merit. PRP use has been promoted by equipment companies such as MTF Sports Medicine, Biomet, and Arteriocyte, but others are likely to take advantage of the trend of increasing PRP use by developing a proprietary injectable that mixes PRP with certain growth factors. One possible addition would be a recombinant platelet-derived growth factor (rhPDGF-BB, be-caplermin) being developed by BioMimetic Therapeutics for its bone graft product.

On the topic of viscosupplementation, the US’s only single-injection product, Genzyme’s SynviscOne®, was noticeably missing from the exhibit hall at AAOS, but an abstract comparing the single- and multiple-injection viscosupplementation techniques demonstrated that single-injection acts faster and is longer lasting.

New bone morphogenetic protein formulations may improve healing of bone fractures.

Molecular diagnostics may be used to predict periprosthetic joint infection, allowing orthopedic medicine to be more personalized. A diagnostic that can be used on a large scale has not yet been identified.

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Notes

  1. Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International.

  2. American Shoulder and Elbow Surgeons self report.

References

  1. Castillo TN, Pouliot MA, Kim HJ, et al. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med 2011 Feb; 39 (2): 266–71

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  2. Hoggatt J. Hot ortho-biologic topics at AAOS 2011: platelet-rich plasma and related growth factors generate excitement. inThought Research, 2011 Feb 28

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Acknowledgments and Disclosures

The original in Thought™ Research Report[2] this article is adapted from is available on request from biodrugs@adis.co.nz. Wolters Kluwer in Thought™ Research Reports provide unbiased analysis and ideas based on the needs and direction of clients. Analyses include a proprietary methodology for quantifying probability of FDA approval as well as a forecasting revenue methodology for both approved and developmental drugs and medical devices. The material herein, while not guaranteed, is based upon information believed to be reliable and accurate. in Thought do not (a) give investment advice; or (b) advocate the sale or purchase of any security or investment. The material herein is not to be deemed an offer or solicitation on our part with respect to the sale or purchase of any securities.

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Correspondence to Julie Hoggatt MAcc.

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Adapted and reproduced from Hoggatt J. Hot Ortho-Biologic Topics at AAOS 2011: Platelet-Rich Plasma and Related Growth Factors Generate Excitement. inThought Research, 2011 Feb 28

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Hoggatt, J. Hot Ortho-Biologic Topics at AAOS 2011. BioDrugs 25, 197–202 (2011). https://doi.org/10.2165/11592710-000000000-00000

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