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Lipids changes in liver cancer

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Abstract

Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.

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References

  • Albers, J.J., Adolphson, J.L., Hazzard, W.R., 1977. Radioimmunoassay of human plasma Lp(a) lipoprotein. J. Lipid. Res., 18:331–338.

    PubMed  CAS  Google Scholar 

  • Artl, A., Marsche, G., Pussinen, P., Knipping, G., Sattler, W., Malle, E., 2002. Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line. Int. J. Biochem. Cell Biol., 34(4):370–381. [doi:10.1016/S1357-2725(01)00132-7]

    Article  PubMed  CAS  Google Scholar 

  • Assmann, G., Schriewer, H., 1980. HDL cholesterol: biochemical aspects. Klin. Wochenschr., 58(15):749–756 (in German). [doi:10.1007/BF01478282]

    Article  PubMed  CAS  Google Scholar 

  • Bae, E.S., Jung, J.W., Jang, J.Y., Choi, S.K., Yoon, S.H.C., 2002. Clinical significance of correlation between COX-2 and CD34-expression in dysplastic nodules. Hepatology, 36:445A.

    Article  Google Scholar 

  • Bamberger, M., Glick, J.M., Rothblat, G.H., 1983. Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells. J. Lipid. Res., 24:869–876.

    PubMed  CAS  Google Scholar 

  • Basili, S., Andreozzi, P., Vieri, M., Maurelli, M., Cara, D., Cordova, C., Alessandri, C., 1997. Lipoprotein(a) serum levels in patients with hepatocarcinoma. Clin. Chim. Acta, 262(1–2):53–60. [doi:10.1016/S0009-8981(97)06533-9]

    Article  PubMed  CAS  Google Scholar 

  • Bégin, M.E., Das, U.N., Ells, G., Horrobin, D.F., 1985. Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukot. Med., 19(2):177–186. [doi:10.1016/0262-1746(85)90084-8]

    Article  PubMed  Google Scholar 

  • Bégin, M.E., Ells, G., Das, U.N., Horrobin, D.F., 1986. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. J. Natl. Cancer Inst., 77:1053–1062.

    PubMed  Google Scholar 

  • Booth, S., Clifton, P.M., Nestel, P.J., 1991. Lack of effect of acute alcohol ingestion on plasma lipids. Clin. Chem., 37:1649.

    PubMed  CAS  Google Scholar 

  • Bravo, E., Carpinelli, G., Proietti, E., Belardelli, F., Cantafora, A., Podo, F., 1990. Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor-alpha. FEBS Lett., 260(2):225–228. [doi:10.1016/0014-5793(90)80108-U]

    Article  Google Scholar 

  • Brinton, E.A., 1996. Oral estrogen replacement therapy in postmenopausal women selectively raises levels and production rates of lipoprotein A-I and lowers hepatic lipase activity without lowering the fractional catabolic rate. Arterioscler. Thromb. Vasc. Biol., 16:431–440.

    PubMed  CAS  Google Scholar 

  • Busch, S.J., Barnhart, R.L., Martin, G.A., Fitzgerald, M.C., Yates, M.T., Mao, S.J., Thomas, C.E., Jackson, R.L., 1994. Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J. Biol. Chem., 269: 16376–16382.

    PubMed  CAS  Google Scholar 

  • Cambien, F., Ducimetiere, P., Richard, J., 1980. Total serum cholesterol and cancer mortality in a middle-aged male population. Am. J. Epidemiol., 112:388–394.

    PubMed  CAS  Google Scholar 

  • Carter, C.A., 2000. Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer. Curr. Drug Targets, 1(2):163–183. [doi:10.2174/1389450003349317]

    Article  PubMed  CAS  Google Scholar 

  • Casey, P.J., Solski, P.A., Der, C.J., Buss, J.E., 1989. p21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. (USA), 86(21):8323–8327. [doi:10.1073/pnas.86.21.8323]

    Article  CAS  Google Scholar 

  • Charpentier, D., Tremblay, C., Rassart, E., Rhainds, D., Auger, A., Milne, R.W., Brissette, L., 2000. Low-and high-density lipoprotein metabolism in HepG2 cells expressing various levels of apolipoprotein E. Biochemistry, 39(51):16084–16091. [doi:10.1021/bi001436u]

    Article  PubMed  CAS  Google Scholar 

  • Chu, A.C., Tsang, S.Y., Lo, E.H., Fung, K.P., 2001. Low density lipoprotein as a targeted carrier for doxorubicin in nude mice bearing human hepatoma HepG2 cells. Life Sci., 70(5):591–601. [doi:10.1016/S0024-3205(01)01441-2]

    Article  PubMed  CAS  Google Scholar 

  • Cicognani, C., Malavolti, M., Morselli-Labate, A.M., Zamboni, L., Sama, C., Barbara, L., 1997. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch. Intern. Med., 157(7): 792–796. [doi:10.1001/archinte.157.7.792]

    Article  PubMed  CAS  Google Scholar 

  • Cooper, M.E., Akdeniz, A., Hardy, K.J., 1996. Effects of liver transplantation and resection on lipid parameters: a longitudinal study. Aust. N. Z. J. Surg., 66:743–746.

    PubMed  CAS  Google Scholar 

  • Cowen, A.E., Campbell, C.B., 1977. Bile salt metabolism. I. The physiology of bile salts. Aust. N. Z. J. Med., 7:579–586.

    PubMed  CAS  Google Scholar 

  • Curtiss, L.K., Boisvert, W.A., 2000. Apolipoprotein E and atherosclerosis. Curr. Opin. Lipidol., 11(3):243–251. [doi:10.1097/00041433-200006000-00004]

    Article  PubMed  CAS  Google Scholar 

  • Davis, R., Bryson, H.M., 1994. Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs, 47:677–700.

    PubMed  CAS  Google Scholar 

  • de Alaniz, M.J., Marra, C.A., 1994. Role of delta 9 desaturase activity in the maintenance of high levels of monoenoic fatty acids in hepatoma cultured cells. Mol. Cell. Biochem., 137(1):85–90. [doi:10.1007/BF00926043]

    Article  PubMed  Google Scholar 

  • Dessì, S., Batetta, B., Pulisci, D., Spano, O., Anchisi, C., Tessitore, L., Costelli, P., Baccino, F.M., Aroasio, E., Pani, P., 1994. Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer. Cancer, 73(2):253–258. [doi:10.1002/1097-0142(19940115)73:2〈253::AID-CNCR2820730204〉3.0.CO;2-F]

    Article  PubMed  Google Scholar 

  • Donnelly, K.L., Smith, C.I., Schwarzenberg, S.J., Jessurun, J., Boldt, M.D., Parks, E.J., 2005. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest., 115(5):1343–1351. [doi:10.1172/JCI200523621]

    Article  PubMed  CAS  Google Scholar 

  • Dugi, K.A., Vaisman, B.L., Sakai, N., Knapper, C.L., Meyn, S.M., Brewer, H.B.Jr, Santamarina-Fojo, S., 1997. Adenovirus-mediated expression of hepatic lipase in LCAT transgenic mice. J. Lipid. Res., 38:1822–1832.

    PubMed  CAS  Google Scholar 

  • Dugi, K.A., Brandauer, K., Schmidt, N., Nau, B., Schneider, J.G., Mentz, S., Keiper, T., Schaefer, J.R., Meissner, C., Kather, H., Bahner, M.L., Fiehn, W., Kreuzer, J., 2001. Low hepatic lipase activity is a novel risk factor for coronary artery disease. Circulation, 104:3057–3062.

    PubMed  CAS  Google Scholar 

  • Eggerman, T.L., Hoeg, J.M., Meng, M.S., Tombragel, A., Bojanovski, D., Brewer, H.B.Jr, 1991. Differential tissue-specific expression of human apoA-I and apoA-II. J. Lipid. Res., 32:821–828.

    PubMed  CAS  Google Scholar 

  • Eisenberg, S., Levy, R.I., 1975. Lipoprotein metabolism. Adv. Lipid. Res., 13:1–89.

    PubMed  CAS  Google Scholar 

  • Fazio, S., Yao, Z., 1995. The enhanced association of apolipoprotein E with apolipoprotein B-containing lipoproteins in serum-stimulated hepatocytes occurs intracellularly. Arterioscler. Thromb. Vasc. Biol., 15:593–600.

    PubMed  CAS  Google Scholar 

  • Fielding, C.J., Fielding, P.E., 1995. Molecular physiology of reverse cholesterol transport. J. Lipid. Res., 36:211–228.

    PubMed  CAS  Google Scholar 

  • Fox, J.C., Hay, R.V., 1992. Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures. Biochem. J., 286(Pt 1):305–312.

    PubMed  CAS  Google Scholar 

  • Frederick, G.L., Begg, R.W., 1956. A study of hyperlipemia in the tumor-bearing rat. Cancer Res., 16:548–552.

    PubMed  CAS  Google Scholar 

  • Fujiyama-Fujiwara, Y., Umeda, R., Igarashi, O., 1992. Metabolism of arachidonic, eicosapentaenoic, and docosahexaenoic acids in HepG2 cells and rat hepatocytes. J. Nutr. Sci. Vitaminol. (Tokyo), 38:329–334.

    CAS  Google Scholar 

  • Funahashi, T., Yokoyama, S., Yamamoto, A., 1989. Association of apolipoprotein E with the low density lipoprotein receptor: demonstration of its cooperativity on lipid microemulsion particles. J. Biochem. (Tokyo), 105:582–587.

    CAS  Google Scholar 

  • Garcia, A., Barbaras, R., Collet, X., Bogyo, A., Chap, H., Perret, B., 1996. High-density lipoprotein 3 receptordependent endocytosis pathway in a human hepatoma cell line (HepG2). Biochemistry, 35(40):13064–13071. [doi:10.1021/bi952223l]

    Article  PubMed  CAS  Google Scholar 

  • Geiss, H.C., Ritter, M.M., Richter, W.O., Schwandt, P., Zachoval, R., 1996. Low lipoprotein (a) levels during acute viral hepatitis. Hepatology, 24(6):1334–1337. [doi:10.1002/hep.510240602]

    Article  PubMed  CAS  Google Scholar 

  • Genest, J.J., Mcnamara, J.R., Ordovas, J.M., Martin-Munley, S., Jenner, J.L., Millar, J., Salem, D.N., Schaefer, E.J., 1990. Effect of elective hospitalization on plasma lipoprotein cholesterol and apolipoproteins A-I, B and Lp(a). Am. J. Cardiol., 65(9):677–679. [doi:10.1016/0002-9149(90)91052-8]

    Article  PubMed  CAS  Google Scholar 

  • Gifford, G.E., Lohmann-Matthes, M.L., 1987. Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide. J. Natl. Cancer Inst., 78:121–124.

    PubMed  CAS  Google Scholar 

  • Greco, A.V., Mingrone, G., Gasbarrini, G., 1995. Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. Clin. Chim. Acta, 239(1): 13–22. [doi:10.1016/0009-8981(95)06093-S]

    Article  PubMed  CAS  Google Scholar 

  • Grünler, J., Olsson, J.M., Dallner, G., 1995. Estimation of dolichol and cholesterol synthesis in microsomes and peroxisomes isolated from rat liver. FEBS Lett., 358(3):230–232. [doi:10.1016/0014-5793(94)01431-Y]

    Article  PubMed  Google Scholar 

  • Guan, Z.Q., Dong, Z.H., Wang, Q.H., Cao, D.X., Fang, Y.Y., Li, H.T., Uchenna, H.I., 2004. Cost of chronic hepatitis B infection in China. J. Clin. Gastroenterol., 38(Suppl. 3):175–178. [doi:10.1097/00004836-200411003-00010]

    Google Scholar 

  • Hachem, H., Favre, G., Raynal, G., Blavy, G., Canal, P., Soula, G., 1986. Serum apolipoproteins A-I, A-II and B in hepatic metastases. Comparison with other liver diseases: hepatomas and cirrhosis. J. Clin. Chem. Clin. Biochem., 24:161–166.

    PubMed  CAS  Google Scholar 

  • Hanai, T., Hashimoto, T., Nishiwaki, K., Ono, M., Akamo, Y., Tanaka, M., Mizuno, I., Yura, J., 1993. Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. J. Surg. Res., 54(1):57–60. [doi:10.1006/jsre.1993.1010]

    Article  PubMed  CAS  Google Scholar 

  • Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K.A., Beisiegel, U., 2004. Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. J. Biol. Chem., 279(53): 55483–55492. [doi:10.1074/jbc.M409324200]

    Article  PubMed  CAS  Google Scholar 

  • Higuchi, K., Hospattankar, A.V., Law, S.W., Meglin, N., Cortright, J., Brewer, H.B.Jr, 1988. Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine. Proc. Natl. Acad. Sci. (USA), 85(6):1772–1776. [doi:10.1073/pnas.85.6.1772]

    Article  CAS  Google Scholar 

  • Hildebrandt, L.A., Spennetta, T., Elson, C., Shrago, E., 1995. Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells. Am. J. Physiol., 269:C22–C27.

    PubMed  CAS  Google Scholar 

  • Hirano, R., Igarashi, O., Kondo, K., Itakura, H., Matsumoto, A., 2001. Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells. Lipids, 36(4):401–406. [doi:10.1007/s11745-001-0735-3]

    Article  PubMed  CAS  Google Scholar 

  • Hiraoka, H., Yamashita, S., Matsuzawa, Y., Kubo, M., Nozaki, S., Sakai, N., Hirano, K., Kawata, S., Tarui, S., 1993. Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: relationship to abnormalities in high-density lipoprotein. Hepatology, 18(1):103–110. [doi:10.1002/hep.1840180117]

    PubMed  CAS  Google Scholar 

  • Hoeg, J.M., Demosky, S.J.Jr, Edge, S.B., Gregg, R.E., Osborne, J.C.Jr, Brewer, H.B.Jr, 1985. Characterization of a human hepatic receptor for high density lipoproteins. Arteriosclerosis, 5:228–237.

    PubMed  CAS  Google Scholar 

  • Hostmark, A.T., Lystad, E., 1992. Growth inhibition of human hepatoma cells (HepG2) by polyunsaturated fatty acids. Protection by albumin and vitamin E. Acta Physiol. Scand., 144:83–88.

    CAS  Google Scholar 

  • Hu, K.Q., 2003. Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases. Prostaglandins Leukot. Essent. Fatty Acids, 69(5):329–337. [doi:10.1016/j.plefa.2003.07.001]

    Article  PubMed  CAS  Google Scholar 

  • Huard, K., Bourgeois, P., Rhainds, D., Falstrault, L., Cohn, J.S., Brissette, L., 2005. Apolipoproteins C-II and C-III inhibit selective uptake of low-and high-density lipoprotein cholesteryl esters in HepG2 cells. Int. J. Biochem. Cell Biol., 37(6):1308–1318. [doi:10.1016/j.biocel.2005.01.005]

    Article  PubMed  CAS  Google Scholar 

  • Iguchi, T., Takasugi, N., Nishimura, N., Kusunoki, S., 1989. Correlation between mammary tumor and blood glucose, serum insulin, and free fatty acids in mice. Cancer Res., 49:821–825.

    PubMed  CAS  Google Scholar 

  • Kader, A., Davis, P.J., Kara, M., Liu, H., 1998. Drug targeting using low density lipoprotein (LDL): physicochemical factors affecting drug loading into LDL particles. J. Control. Rel., 55(2–3):231–243. [doi:10.1016/S0168-3659(98)00052-2]

    Article  CAS  Google Scholar 

  • Kanel, G.C., Radvan, G., Peters, R.L., 1983. High-density lipoprotein cholesterol and liver disease. Hepatology, 3:343–348.

    Article  PubMed  CAS  Google Scholar 

  • Kang, S.K., Chung, T.W., Lee, J.Y., Lee, Y.C., Morton, R.E., Kim, C.H., 2004. The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III. J. Biol. Chem., 279(27):28106–28112. [doi:10.1074/jbc.M403176200]

    Article  PubMed  CAS  Google Scholar 

  • Katsuramaki, T., Hirata, K., Kimura, Y., Nagayama, M., Meguro, M., Kimura, H., Honma, T., Furuhata, T., Hideki, U., Hata, F., Mukaiya, M., 2002. Changes in serum levels of apolipoprotein A-1 as an indicator of protein metabolism after hepatectomy. Wound Repair and Regeneration, 10(1):77–82. [doi:10.1046/j.1524-475X.2002.10602.x]

    Article  PubMed  Google Scholar 

  • Keler, T., Barker, C.S., Sorof, S., 1992. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. Proc. Natl. Acad. Sci. (USA), 89(11):4830–4834. [doi:10.1073/pnas.89.11.4830]

    Article  CAS  Google Scholar 

  • Koga, H., Sakisaka, S., Ohishi, M., Kawaguchi, T., Taniguchi, E., Sasatomi, K., Harada, M., Kusaba, T., Tanaka, M., Kimura, R., et al., 1999. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology, 29(3):688–696. [doi:10.1002/hep.510290355]

    Article  PubMed  CAS  Google Scholar 

  • Kondo, M., Yamamoto, H., Nagano, H., Okami, J., Ito, Y., Shimizu, J., Eguchi, H., Miyamoto, A., Dono, K., Umeshita, K., et al., 1999. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5:4005–4012.

    PubMed  CAS  Google Scholar 

  • Kostner, G.M., 1983. Apolipoproteins and lipoproteins of human plasma: significance in health and in disease. Adv. Lipid. Res., 20:1–43.

    PubMed  CAS  Google Scholar 

  • Kraft, H.G., Menzel, H.J., Hoppichler, F., Vogel, W., Utermann, G., 1989. Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis. J. Clin. Invest., 83:137–142.

    PubMed  CAS  Google Scholar 

  • Krempler, F., Kostner, G.M., Bolzano, K., Sandhofer, F., 1980. Turnover of lipoprotein (a) in man. J. Clin. Invest., 65:1483–1490.

    PubMed  CAS  Google Scholar 

  • Krempler, F., Kostner, G.M., Roscher, A., Haslauer, F., Bolzano, K., Sandhofer, F., 1983. Studies on the role of specific cell surface receptors in the removal of lipoprotein (a) in man. J. Clin. Invest., 71:1431–1441.

    Article  PubMed  CAS  Google Scholar 

  • Krieger, M., 1999. Charting the fate of the “good cholesterol”: identification and characterization of the high-density lipoprotein receptor SR-BI. Annu. Rev. Biochem., 68(1): 523–558. [doi:10.1146/annurev.biochem.68.1.523]

    Article  PubMed  CAS  Google Scholar 

  • Krisans, S.K., 1996. Cell compartmentalization of cholesterol biosynthesis. Ann. N. Y. Acad. Sci., 804(1):142–164. [doi:10.1111/j.1749-6632.1996.tb18614.x]

    Article  PubMed  CAS  Google Scholar 

  • Kumar, K., Sachdanandam, P., Arivazhagan, R., 1991. Studies on the changes in plasma lipids and lipoproteins in patients with benign and malignant breast cancer. Biochem. Int., 23:581–589.

    PubMed  CAS  Google Scholar 

  • Langstein, H.N., Norton, J.A., 1991. Mechanisms of cancer cachexia. Hematol. Oncol. Clin. North. Am., 5:103–123.

    PubMed  CAS  Google Scholar 

  • Law, M.R., Thompson, S.G., 1991. Low serum cholesterol and the risk of cancer: an analysis of the published prospective studies. Cancer Causes and Control, 2(4):253–261. [doi:10.1007/BF00052142]

    Article  PubMed  CAS  Google Scholar 

  • Levi, S., 1972. Estimation of fetal age: ultrasonics and other methods. J. Gynecol. Obstet. Biol. Reprod. (Paris), 1:314–315.

    CAS  Google Scholar 

  • Lewis, G.F., Rader, D.J., 2005. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ. Res., 96(12):1221–1232. [doi:10.1161/01.RES.0000170946.56981.5c]

    Article  PubMed  CAS  Google Scholar 

  • Lin, C., Blank, W., Ceriani, R.L., Baker, N., 1992. Effect of human mammary MX-1 tumor on plasma free fatty acids in fasted and fasted-refed nude mice. Lipids, 27(1):33–37. [doi:10.1007/BF02537055]

    Article  PubMed  CAS  Google Scholar 

  • Lou, B., Liao, X.L., Wu, M.P., Cheng, P.F., Yin, C.Y., Fei, Z., 2005. High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells. World J. Gastroenterol., 11:954–959.

    PubMed  CAS  Google Scholar 

  • Maeda, S., Abe, A., Seishima, M., Makino, K., Noma, A., Kawade, M., 1989. Transient changes of serum lipoprotein(a) as an acute phase protein. Atherosclerosis, 78(2–3):145–150. [doi:10.1016/0021-9150(89)90218-9]

    Article  PubMed  CAS  Google Scholar 

  • Malaguarnera, M., Trovato, G., Restuccia, S., Giugno, I., Franze, C.M., Receputo, G., Siciliano, R., Motta, M., Trovato, B.A., 1994. Treatment of nonresectable hepatocellular carcinoma: review of the literature and meta-analysis. Adv. Ther., 11:303–319.

    PubMed  CAS  Google Scholar 

  • Malaguarnera, M., Giugno, I., Trovato, B.A., Panebianco, M.P., Restuccia, N., Ruello, P., 1996. Lipoprotein(a) in cirrhosis. A new index of liver functions? Curr. Med. Res. Opin., 13:479–485.

    Article  PubMed  CAS  Google Scholar 

  • Malmendier, C.L., Lontie, J.F., Mathe, D., Adam, R., Bismuth, H., 1992. Lipid and apolipoprotein changes after orthotopic liver transplantation for end-stage liver diseases. Clin. Chim. Acta, 209(3):169–177. [doi:10.1016/0009-8981(92)90165-M]

    Article  PubMed  CAS  Google Scholar 

  • Marques-Vidal, P., Azema, C., Collet, X., Vieu, C., Chap, H., Perret, B., 1994. Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition. J. Lipid. Res., 35:373–384.

    PubMed  CAS  Google Scholar 

  • Matsuura, T., Koga, S., Ibayashi, H., 1988. Increased proportion of proapolipoprotein A-I in HDL from patients with liver cirrhosis and hepatitis. Gastroenterol. Jpn., 23:394–400.

    PubMed  CAS  Google Scholar 

  • Mendez, A.J., Oram, J.F., Bierman, E.L., 1991. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J. Biol. Chem., 266:10104–10111.

    PubMed  CAS  Google Scholar 

  • Mermier, P., Baker, N., 1974. Flux of free fatty acids among host tissues, ascites fluid, and Ehrlich ascites carcinoma cells. J. Lipid. Res., 15:339–351.

    PubMed  CAS  Google Scholar 

  • Miura, Y., Ono, K., Okauchi, R., Yagasaki, K., 2004. Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatoma-bearing rats. J. Nutr. Sci. Vitaminol. (Tokyo), 50:38–44.

    CAS  Google Scholar 

  • Montaguti, U., Sangiorgi, Z., Descovich, G.C., 1975. The liver and abnormal lipoproteins. Minerva. Med., 66: 3428–3437.

    PubMed  CAS  Google Scholar 

  • Motta, M., Giugno, I., Ruello, P., Pistone, G., Di Fazio, I., Malaguarnera, M., 2001. Lipoprotein(a) behaviour in patients with hepatocellular carcinoma. Minerva. Med., 92:301–305.

    PubMed  CAS  Google Scholar 

  • Mulcahy, J.V., Riddell, D.R., Owen, J.S., 2004. Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux. Biochem. J., 377:741–747.

    PubMed  CAS  Google Scholar 

  • Nissen, N.N., Martin, P., 2002. Hepatocellular carcinoma: the high-risk patient. J. Clin. Gastroenterol., 35(5):S79–S85. [doi:10.1097/00004836-200211002-00003]

    Article  PubMed  CAS  Google Scholar 

  • Ockner, R.K., Kaikaus, R.M., Bass, N.M., 1993. Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: review and hypothesis. Hepatology, 18(3): 669–676. [doi:10.1002/hep.1840180327]

    Article  PubMed  CAS  Google Scholar 

  • Okuno, K., Jinnai, H., Lee, Y.S., Nakamura, K., Hirohata, T., Shigeoka, H., Yasutomi, M., 1995. A high level of prostaglandin E2 (PGE2) in the portal vein suppresses liver-associated immunity and promotes liver metastases. Surg. Today, 25(11):954–958. [doi:10.1007/BF00312380]

    Article  PubMed  CAS  Google Scholar 

  • Ooi, K., Shiraki, K., Sakurai, Y., Morishita, Y., Nobori, T., 2005. Clinical significance of abnormal lipoprotein patterns in liver diseases. Int. J. Mol. Med., 15:655–660.

    PubMed  CAS  Google Scholar 

  • Palut, D., 1997. Proliferation of peroxisomes and the hepatocarcinogenic process. Rocz. Panstw. Zakl. Hig., 48:1–11.

    PubMed  CAS  Google Scholar 

  • Pangburn, S.H., Newton, R.S., Chang, C.M., Weinstein, D.B., Steinberg, D., 1981. Receptor-mediated catabolism of homologous low density lipoproteins in cultured pig hepatocytes. J. Biol. Chem., 256:3340–3347.

    PubMed  CAS  Google Scholar 

  • Parkin, D.M., Bray, F., Ferlay, J., Pisani, P., 2001. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer, 94(2):153–156. [doi:10.1002/ijc.1440]

    Article  PubMed  CAS  Google Scholar 

  • Perletti, G., Tessitore, L., Sesca, E., Pani, P., Dianzani, M.U., Piccinini, F., 1996. Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture. Biochem. Biophys. Res. Commun., 221(3):688–691. [doi:10.1006/bbrc.1996.0657]

    Article  PubMed  CAS  Google Scholar 

  • Phillips, G.B., 1960. The lipid composition of serum in patients with liver disease. J. Clin. Invest., 39:1639–1650.

    PubMed  CAS  Google Scholar 

  • Popescu, I., Simionescu, M., Tulbure, D., Sima, A., Catana, C., Niculescu, L., Hancu, N., Gheorghe, L., Mihaila, M., Ciurea, S., Vidu, V., 2003. Homozygous familial hypercholesterolemia: specific indication for domino liver transplantation. Transplantation, 76(9):1345–1350. [doi:10.1097/01.TP.0000093996.96158.44]

    Article  PubMed  CAS  Google Scholar 

  • Ramesh, G., Das, U.N., 1995. Effect of dietary fat on diethyl-nitrosamine induced hepatocarcinogenesis in Wistar rats. Cancer Lett., 95(1–2):237–245. [doi:10.1016/0304-3835(95)03896-5]

    Article  PubMed  CAS  Google Scholar 

  • Rinninger, F., Mann, W.A., Kaiser, T., Ahle, S., Meyer, N., Greten, H., 1998. Hepatic lipase mediates an increase in selective uptake of high-density lipoprotein-associated cholesteryl esters by human Hep 3B hepatoma cells in culture. Atherosclerosis, 141(2):273–285. [doi:10.1016/S0021-9150(98)00181-6]

    Article  PubMed  CAS  Google Scholar 

  • Rothblat, G.H., Phillips, M.C., 1986. Cholesterol efflux: mechanism and regulation. Adv. Exp. Med. Biol., 201:195–204.

    PubMed  CAS  Google Scholar 

  • Rubies-Prat, J., Masana, L., Masdeu, S., Nubiola, A.R., Chacon, P., 1983. Hypercholesterolemia associated with hepatocarcinoma. Med. Clin. (Barc), 80:175–176.

    CAS  Google Scholar 

  • Samonakis, D.N., Koutroubakis, I.E., Sfiridaki, A., Malliraki, N., Antoniou, P., Romanos, J., Kouroumalis, E.A., 2004. Hypercoagulable states in patients with hepatocellular carcinoma. Dig. Dis. Sci., 49(5):854–858. [doi:10.1023/B:DDAS.0000030099.13397.28]

    Article  PubMed  CAS  Google Scholar 

  • Santamarina-Fojo, S., Haudenschild, C., Amar, M., 1998. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr. Opin. Lipidol., 9:211–219. [doi:10.1097/00041433-199806000-00005]

    Article  PubMed  CAS  Google Scholar 

  • Sherlock, D.S., 1995. Alcoholic liver disease. Lancet, 345(8944):227–229. [doi:10.1016/S0140-6736(95)90226-0]

    Article  PubMed  CAS  Google Scholar 

  • Sherlock, S., Dooley, I., 1993. Disease of the Liver and Biliary System, 9th Ed. Kubik Fine Books Ltd., USA, p.503–531.

    Google Scholar 

  • Shi, J., Zhu, L., Liu, S., Xie, W.F., 2005. A meta-analysis of case-control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China. Br. J. Cancer, 92(5):607–612. [doi:10.1038/sj.bjc.6602333]

    Article  PubMed  CAS  Google Scholar 

  • Shiota, G., Okubo, M., Noumi, T., Noguchi, N., Oyama, K., Takano, Y., Yashima, K., Kishimoto, Y., Kawasaki, H., 1999. Cyclooxygenase-2 expression in hepatocellular carcinoma. Hepatogastroenterology, 46:407–412.

    PubMed  CAS  Google Scholar 

  • Silver, D.L., Wang, N., Tall, A.R., 2000. Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake. J. Clin. Invest., 105:151–159.

    PubMed  CAS  Google Scholar 

  • Skipski, V.P., Barclay, M., Archibald, F.M., Stock, C.C., 1975. Tumor proteolipids. Prog. Biochem. Pharmacol., 10: 112–134.

    PubMed  CAS  Google Scholar 

  • Spector, A.A., 1967. The importance of free fatty acid in tumor nutrition. Cancer Res., 27:1580–1586.

    PubMed  CAS  Google Scholar 

  • Sviridov, D., Fidge, N., 1995. Pathway of cholesterol efflux from human hepatoma cells. Biochim. Biophys. Acta, 1256:210–220.

    PubMed  Google Scholar 

  • Sviridov, D., Nestel, P., 2002. Dynamics of reverse cholesterol transport: protection against atherosclerosis. Atherosclerosis, 161(2):245–254. [doi:10.1016/S0021-9150(01)00677-3]

    Article  PubMed  CAS  Google Scholar 

  • Sviridov, D., Sasahara, T., Pyle, L.E., Nestel, P.J., Fidge, N.H., 1997. Antibodies against high-density lipoprotein binding proteins enhance high-density lipoprotein uptake but do not affect cholesterol efflux from rat hepatoma cells. Int. J. Biochem. Cell Biol., 29(4):583–588. [doi:10.1016/S1357-2725(96)00174-4]

    Article  PubMed  CAS  Google Scholar 

  • Tall, A.R., Jiang, X., Luo, Y., Silver, D., 2000. 1999 George Lyman Duff memorial lecture: lipid transfer proteins, HDL metabolism, and atherogenesis. Arterioscler. Thromb. Vasc. Biol., 20:1185–1188.

    PubMed  CAS  Google Scholar 

  • Tan, K.C., Shiu, S.W., Pang, R.W., Kung, A.W., 1998. Effects of testosterone replacement on HDL subfractions and apolipoprotein A-I containing lipoproteins. Clin. Endocrinol. (Oxf), 48(2):187–194. [doi:10.1046/j.1365-2265.1998.3721211.x]

    CAS  Google Scholar 

  • Tietge, U.J., Boker, K.H., Bahr, M.J., Weinberg, S., Pichlmayr, R., Schmidt, H.H., Manns, M.P., 1998. Lipid parameters predicting liver function in patients with cirrhosis and after liver transplantation. Hepatogastroenterology, 45:2255–2260.

    PubMed  CAS  Google Scholar 

  • Tracey, K.J., Lowry, S.F., Cerami, A., 1988. Cachectin: a hormone that triggers acute shock and chronic cachexia. J. Infect. Dis., 157:413–420.

    PubMed  CAS  Google Scholar 

  • Trigatti, B., Rigotti, A., Krieger, M., 2000. The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism. Curr. Opin. Lipidol., 11(2):123–131. [doi:10.1097/00041433-200004000-00004]

    Article  PubMed  CAS  Google Scholar 

  • Tu, L.C., Chou, C.K., Chen, H.C., Yeh, S.F., 2001. Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. J. Biomed. Sci., 8(2):184–190. [doi:10.1007/BF02256411]

    Article  PubMed  CAS  Google Scholar 

  • von Eckardstein, A., Huang, Y., Assmann, G., 1994. Physiological role and clinical relevance of high-density lipoprotein subclasses. Curr. Opin. Lipidol., 5(6):404–416. [doi:10.1097/00041433-199412000-00003]

    Article  Google Scholar 

  • Williams, R.R., Sorlie, P.D., Feinleib, M., Mcnamra, P.M., Kannel, W.B., Dawber, T.R., 1981. Cancer incidence by levels of cholesterol. JAMA, 245(3):247–252. [doi:10.1001/jama.245.3.247]

    Article  PubMed  CAS  Google Scholar 

  • Zhang, S.W., Li, L.D., Lu, F.Z., 1999. Mortality of primary liver cancer in China from 1990 through 1992. Chinese Journal of Oncology, 21:245–249 (in Chinese).

    PubMed  CAS  Google Scholar 

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Jiang, Jt., Xu, N., Zhang, Xy. et al. Lipids changes in liver cancer. J. Zhejiang Univ. - Sci. B 8, 398–409 (2007). https://doi.org/10.1631/jzus.2007.B0398

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