Chest
Serum Neuron-Specific Enolase: A Marker for Disease Extent and Response to Therapy for Small-Cell Lung Cancer
Section snippets
Subjects
Serum samples were obtained from 56 patients with histologically confirmed SCLC undergoing protocol staging procedures including physical examination; chest roentgenogram; fiberoptic bronchoscopy (with bronchial biopsy); radionuclide scan of bones; liver echography; brain CT scan; and bone-marrow biopsy. Biopsy specimens of enlarged lymph nodes, subcutaneous nodules, and pleural effusions were taken when clinically indicated. Forty-three patients with SCLC were staged as having limited disease
RESULTS
Mean S-NSE level in controls was 6 ± 5 [SE] ng/ml (range 1 to 22 ng/ml, median 4 ng/ml). Levels equal to or greater than 16 ng/ml were considered raised since this value is almost 2 SD above the mean.
DISCUSSION
Raised S-NSE levels were found in 65.1 percent of all SCLC patients at diagnosis; this percentage is similar to those already reported by Carney et alu (69 percent) and by Ariyoshi et al12 (65 percent), although these authors defined “raised” S-NSE values respectively above 12 ng/ml and above 7.5 ng/ml. We found raised S-NSE levels in 37.5 percent of patients with limited stage disease and in 78.6 percent of patients with extensive stage disease: percentages found by Carney et al11 for these
ACKNOWLEDGMENT
The authors are grateful to Mrs. J. C. Michalon for her secretarial assistance and to Biomerieux Company (Laboratory of Dr. B. M and rand) for its participation in the antibody production. They wish to acknowledge Mrs. Clarissa Henry and Dr. J. C. Ansquer (Servier Laboratories) for preparation of the manuscript ana Dr. T. Bârzu (Institut Pasteur, Paris) for contributing insights during the course of this work.
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