Chest
Selected ReportsPulmonary Infiltrates Following Administration of Paclitaxel
Section snippets
CASE 1
A 66-year-old white woman with a 40 pack-year history of cigarette smoking presented with recurrent non-small cell lung cancer (NSCLC) in the left lung. Multiple tumor nodules were noted about 2 years after initial surgery for stage I disease. A regimen of carboplatin and paclitaxel combination for metastatic disease was begun. Carboplatin dose was given according to the Calvert et al4 formula with a target area under the time concentration curve (AUC) of 9 mg/mL-min. Paclitaxel was given at
DISCUSSION
Hypersensitivity reactions previously reported with paclitaxel have not been associated with the occurrence of pulmonary infiltrates.1,3 Chemotherapeutic agents that are known to cause pulmonary infiltrates as a part of the hypersensitivity reactions are bleomycin, methotrexate, and procarbazine.5,6 These reactions are often seen within hours to a few days after drug administration. Predominant airway involvement causes an asthma-like syndrome, and patchy eosinophilic infiltrates are seen with
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