Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines

Yukihiro Akao; Hiroe Maruyama; Kenji Matsumoto; Kenji Ohguchi; Kumi Nishizawa; Takashi Sakamoto; Yoko Araki; Satoshi Mishima; Yoshinori Nozawa

doi:10.1248/bpb.26.1057

Communications to the Editor

Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines

Yukihiro Akao, Hiroe Maruyama, Kenji Matsumoto, Kenji Ohguchi, Kumi Nishizawa, Takashi Sakamoto, Yoko Araki, Satoshi Mishima, Yoshinori Nozawa

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Keywords: propolis, drupanin, cell growth inhibition, apoptosis, human tumor cell

JOURNAL FREE ACCESS

2003 Volume 26 Issue 7 Pages 1057-1059

DOI https://doi.org/10.1248/bpb.26.1057

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Abstract

A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.

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