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Breast Reconstruction and Revision Surgery for Implant-associated Breast Deformities Using Porcine Acellular Dermal Matrix: A Multicenter Study of 156 Cases

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Acellular dermal matrix is increasingly used as caudolateral coverage for breast implants in immediate breast reconstruction after skin-sparing mastectomy or in the correction of implant-associated breast deformities. Matrices of human, bovine, and porcine origin are available. The purpose of this retrospective multicenter study was to report experiences with porcine acellular dermal matrices, as only limited data can be found in the literature.

Methods

In the hospital databases of five institutions, 127 patients were identified who underwent breast reconstructions in 156 breasts using an acellular porcine dermal matrix. Medical records were reviewed. Patients were divided into three groups: immediate expander-implant or direct to implant reconstructions (n = 98), delayed expander-implant reconstructions (n = 14), and revision surgery for implant-associated breast deformities (n = 44).

Results

With a mean follow-up of 19.6 months, total major complication rate was 7.1 %: implant loss (3.2 %), skin flap necrosis (2.6 %), delayed skin healing (2.6 %), hematoma (1.9 %), seroma (1.3 %), infection (0.6 %), and capsular contracture (0.6 %). Total minor complication rate was 22.9 %, with seroma being the most frequent complication (19.2 %). In the group of immediate breast reconstructions, 20.4 % of the breasts had received radiotherapy in the past. These patients exhibited a significantly higher rate of seroma than patients without prior radiotherapy (35.0 vs. 14.9 %, p = 0.031).

Conclusions

Complication rates using porcine acellular dermal matrix in breast reconstruction are comparable to complication rates reported in studies using human acellular dermal matrices. Thus, porcine acellular dermal matrices can safely be applied in breast reconstructive surgery.

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Disclosures

NK received travel grants for data collection from LifeCell. RO and SP are consultants for LifeCell. The other authors declare no conflict of interest.

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Correspondence to U. Hille-Betz MD.

Electronic supplementary material

Below is the link to the electronic supplementary material.

10434_2014_4098_MOESM1_ESM.jpg

Supplemental Fig. 1 for online-publication. Complications in the three groups split by radiotherapy application (JPEG 140 kb)

10434_2014_4098_MOESM2_ESM.jpg

Supplemental Fig. 2 for online-publication Patient with 6 cm ductal carcinoma in situ and small invasive carcinoma not eligible for breast conserving therapy before nipple-sparing mastectomy with expander/implant- based breast reconstruction of the right breast with Strattice assistance, frontal view. (JPEG 291 kb)

Supplemental Fig. 3 for online-publication Same patient, lateral view (JPEG 266 kb)

10434_2014_4098_MOESM4_ESM.jpg

Supplemental Fig. 4 for online-publication. Same patient before expander/implant exchange of the right breast and reduction mammaplasty of the left breast for symmetrization, frontal view (JPEG 228 kb)

Supplemental Fig. 5 for online-publication. Same patient, lateral view (JPEG 236 kb)

Supplemental Fig. 6 for online-publication. Same patient 6 months after surgery, frontal view (JPEG 297 kb)

Supplemental Fig. 7 for online publication. Same patient after surgery, lateral view (JPEG 257 kb)

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Hille-Betz, U., Kniebusch, N., Wojcinski, S. et al. Breast Reconstruction and Revision Surgery for Implant-associated Breast Deformities Using Porcine Acellular Dermal Matrix: A Multicenter Study of 156 Cases . Ann Surg Oncol 22, 1146–1152 (2015). https://doi.org/10.1245/s10434-014-4098-3

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  • DOI: https://doi.org/10.1245/s10434-014-4098-3

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