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Pulmonary Resection for Colorectal Cancer Metastases: Duration Between Cancer Onset and Lung Metastasis as an Important Prognostic Factor

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Pulmonary resection is the most effective treatment available for colorectal lung metastases. However, the characteristics of those patients most likely to benefit from surgical resection have not yet been adequately clarified. We have made a critical analysis for the potential prognostic factors and their clinical significance in lung metastasis from colorectal cancer.

Methods

We analyzed 63 consecutive patients who underwent curative pulmonary resection for colorectal lung metastases at National Taiwan University Hospital from January 1997 to December 2006. Median follow-up was 37.3 (range 12–122) months. Disease-free and overall survival rates were evaluated by Kaplan–Meier analysis, and multivariate analyses of various prognostic characteristics were performed.

Results

Overall 5-year survival and disease-free survival rates were 43.9% and 19.5%, respectively. Multivariate analysis showed that the interval for development of lung metastases from primary colorectal cancer and the mode of operation were the only two independent prognostic factors for survival. With regard to disease-free survival, the interval between initial resection of colorectal cancer and following lung metastases was the only significant independent prognostic factor. Besides, subset analysis showed that the 5-year survival rate in repeated resection group for recurrence of colorectal metastasis in residual lung was 85.7%.

Conclusion

Pulmonary resection, initial or even repeated resection for metastatic tumor from colorectal cancer should be encouraged for selected patients as it can significantly improve survival. Patients who have lung metastases within 1 year after primary tumor resection and those who do not undergo anatomical resection for metastatic lung tumor should be followed more carefully due to poor prognosis.

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Acknowledgement

Been-Ren Lin and Tung-Chen Chang contributed equally to this article.

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Authors and Affiliations

  1. Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ROC

    Been-Ren Lin, Tung-Chen Chang, Po-Huang Lee, King-Jen Chang & Jin-Tung Liang

  2. Division of Chest Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ROC

    Yung-Chie Lee

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  1. Been-Ren Lin
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  2. Tung-Chen Chang
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Correspondence to Jin-Tung Liang.

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Lin, BR., Chang, TC., Lee, YC. et al. Pulmonary Resection for Colorectal Cancer Metastases: Duration Between Cancer Onset and Lung Metastasis as an Important Prognostic Factor. Ann Surg Oncol 16, 1026–1032 (2009). https://doi.org/10.1245/s10434-008-0286-3

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  • DOI: https://doi.org/10.1245/s10434-008-0286-3

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