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Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Hepatocellular Carcinoma

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Abstract

Background

Hepatoma-derived growth factor (HDGF) is involved in hepatocarcinogenesis, as well as in liver development and regeneration. This study investigated the correlation of HDGF expression with differentiation and prognosis of hepatocellular carcinoma (HCC).

Methods

HDGF expression in 100 patients with HCC (81 men and 19 women) with ages ranging from 34 to 81 years (median, 61 years) receiving surgical treatment was analyzed by immunohistochemistry. HDGF messenger RNA expression was evaluated in 10 cases by reverse transcription-polymerase chain reaction. The immunostaining pattern in HCCs was categorized as a positive HDGF index (showing positive staining in >90% of tumor cells in both nucleus and cytoplasm) or a negative HDGF index (all others).

Results

Twenty-seven cases (27%) showed a positive and 73 (73%) showed a negative HDGF index. HDGF messenger RNA expression was significantly higher in four cases with a positive HDGF index than in six with a negative index. Cases with well-differentiated histological characteristics showed a higher rate of positive HDGF index than those with a poorly differentiated subtype. Univariate and multivariate analysis revealed significantly poorer disease-free and overall survivals in patients with a positive HDGF index compared with patients with a negative index.

Conclusions

These findings suggest the potential utility of HDGF immunohistochemistry in determining the prognosis of HCC.

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Authors and Affiliations

  1. Department of Molecular Medicine, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, Osaka, 565-0871, Japan

    Kenya Yoshida MD, Yorihide Okuda MD, Hirayuki Enomoto MD, Hirokazu Uyama MD, Hiroaki Ito MD, Ichiro Kawase MD & Hideji Nakamura MD

  2. Department of Pathology, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, Osaka, 565-0871, Japan

    Yasuhiko Tomita MD, Yoshihiko Hoshida MD & Katsuyuki Aozasa MD

  3. Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, Osaka, 565-0871, Japan

    Shinji Yamamoto MD, Hiroaki Nagano MD, Masato Sakon MD & Morito Monden MD

  4. Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, 663-8501, Japan

    Hideji Nakamura MD

Authors
  1. Kenya Yoshida MD
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  2. Yasuhiko Tomita MD
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  3. Yorihide Okuda MD
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  4. Shinji Yamamoto MD
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  5. Hirayuki Enomoto MD
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  6. Hirokazu Uyama MD
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  7. Hiroaki Ito MD
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  8. Yoshihiko Hoshida MD
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  9. Katsuyuki Aozasa MD
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  10. Hiroaki Nagano MD
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  11. Masato Sakon MD
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  12. Ichiro Kawase MD
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  13. Morito Monden MD
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  14. Hideji Nakamura MD
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Corresponding author

Correspondence to Hideji Nakamura MD.

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Yoshida, K., Tomita, Y., Okuda, Y. et al. Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Hepatocellular Carcinoma. Ann Surg Oncol 13, 159–167 (2006). https://doi.org/10.1245/ASO.2006.11.035

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  • DOI: https://doi.org/10.1245/ASO.2006.11.035

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