Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats1
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Key Words
blueberry
gut microbiota
intestinal epithelial barrier
inflammation
insulin signaling
Abbreviations
BW
body weight
Defb2
β-defensin 2
GLP1
glucagon-like peptide 1
GPR
G-protein-coupled receptor
HF
high fat
HF_BB
high fat with 10% blueberry
IRS1
insulin receptor substrate 1
LBP
LPS-binding pro-tein
LF
low fat
Muc2
mucin 2
p-IRS1 (Ser307)
insulin receptor substrate 1 phosphorylation at serine 307
Ppar
peroxisome proliferator-activated receptor
Tnfa
tumor necrosis factor α
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Supported by Agriculture and Food Research Initiative Competitive Grant 2014-67017-21757 from the US Department of AgricultureNational Institute of Food and Agriculture. We acknowledge the University of California, Davis, Host Mi-crobe Systems Biology Core Facility for microbiota sample preparation and sequencing, the Mayo Clinic Metabolomics Core and its supporting grants (U24DK100469 and UL1TR000135) for SCFA analysis, the Vanderbilt University.
Copyright © 2018 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.