Elsevier

Gastrointestinal Endoscopy

Volume 52, Issue 6, December 2000, Pages 755-762
Gastrointestinal Endoscopy

New Methods & Materials
Effectiveness of the near-infrared electronic endoscope for diagnosis of the depth of involvement of gastric cancers,☆☆

https://doi.org/10.1067/mge.2000.110455Get rights and content

Abstract

Background: Near-infrared light penetrates deeply into tissue but is not visible with a conventional endoscope. We developed a new infrared electronic endoscope system and evaluated its usefulness for assessing the depth of involvement of gastric cancers. Methods: A total of 61 patients with depressed or ulcer-ated gastric cancers underwent infrared endoscopy after intravenous injection of indocyanine green. Results: Intramucosal cancers were observed as tumors with or without a homogeneous tumor stain, whereas submucosal or deeper cancers were observed as tumors with an inhomogeneous stain or with pooling of the dye. Histologic examination showed staining properties of gastric cancers were significantly correlated with the characteristics of the vascular bed. The accuracy for depth of cancer invasion was 89% for mucosal cancers and 89% for submucosal or deeper cancers. Conclusion: Our new infrared electronic endoscope sys-tem was useful for distinguishing mucosal cancers from submucosal or deeper cancers either with or without ulcerative changes.

Section snippets

Near-infrared electronic endoscopy system

Our near-infrared electronic endoscopy system is composed of a light source, special filters, a distally mounted charge-coupled device (CCD), and a forward-viewing electronic videoendoscope (GIF-Q200 IR; Olympus Optical Co., Ltd., Tokyo, Japan) (Fig. 1).

. Schematic diagram of the near-infrared electronic endoscope system.

Light produced by a xenon lamp (CLV-U20D IR; Olympus) first passes through either an infrared cut filter or an 805 nm band pass filter. The filters can be selected with a switch

Relationship between infrared endoscopic findings and depth of involvement of cancers

The endoscopic infrared appearance of the tumor and the depth of involvement of the tumors were strongly correlated (Table 1).

. Depth of involvement of gastric cancers in relation to the infrared endoscopic findings*

Empty CellEmpty CellDepth of tumor invasion (%)
Infrared endoscopic findingsMucosalSubmucosal or deeperTotal
No stain3 (100)0 (0)3 (100)
Tumor stain
 Homogeneous6 (75)2 (25)8 (100)
 Inhomogeneous1 (10)10 (90)11 (100)
 Pooling of the dye0 (0)2 (100)2 (100)
*Tumors with an inhomogeneous tumor stain or with pooling

Discussion

Our newly developed infrared electronic endoscope system was found in the present study to be useful for diagnosing the depth of involvement of gastric cancers either with or without ulcerative change.

Our previous development of this method of infrared photography of the human gastric mucosa used a fiberoptic gastroscopic camera and infrared film.16 With this technique, the pattern of deep vessels, which could not be seen with conventional methods, could be clearly visualized. However, this

Acknowledgements

We thank Olympus Optical Co., Ltd., for their technical support.

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    Supported in part by a Grant-in-Aid for the Cancer Research (No. 10-37) from the Ministry of Health and Welfare of Japan.

    ☆☆

    Reprint requests: Kazushige Iseki, MD, Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, Osaka 537-8511, Japan.

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