Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation

Yoshinobu Kiso; Masahiro Tohkin; Hiroshi Hikino; Masao Hattori; Tatsuya Sakamoto; Tsuneo Namba

doi:10.1055/s-2007-969714

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Planta Med 1984; 50(4): 298-302
DOI: 10.1055/s-2007-969714

Research Articles

Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation[1]

Yoshinobu Kiso² , Masahiro Tohkin² , Hiroshi Hikino² , Masao Hattori³ , Tatsuya Sakamoto³ , Tsuneo Namba³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan.
³Research Institute for Wakan-Yaku (Oriental Medicine), Toyama Medical and Pharmaceutical University, Toyama, Japan.

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Publication History

1983

1984

Publication Date:
26 February 2007 (online)

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Abstract

Glycyrrhizin and its analogues were screened for antihepatotoxic activity by in vitro assay methods using carbon tetrachloride (CCl₄)-and galactosarnine-induced cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationship in these substances is discussed. The mechanism of inhibitory activity of glycyrrhizin and glycyrrhetinic acid in CCl₄-produced liver damage was investigated by determining the effects of these substances on the initial steps in the sequence of events leading to liver lesion, revealing that anti-oxidative action plays an important part in the antihepatotoxic activity.

1 Liver-protective drugs, Part 14. Also Part 65 in the Tohoku University series on the validity of Oriental medicines.

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