Planta Med 1995; 61(2): 150-153
DOI: 10.1055/s-2006-958036
Papers

© Georg Thieme Verlag Stuttgart · New York

Pharmacological Effects of Methanolic Extract from the Root of Scutellaria baicalensis and its Flavonoids on Human Gingival Fibroblast

Chong-Pyoung Chung1 , Joon-Bong Park2 , Ki-Hwan Bae3
  • 1College of Dentistry, Seoul National University, Seoul 110-460, Korea
  • 2College of Dentistry, KyungHee University, Seoul 130-701, Korea
  • 3College of Pharmacy, ChungNam National University, Taejon 305-764, Korea
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

Abstract

The methanolic extract from the root of Scutellaria baicalensis Georgi and its flavonoids, wogonin, baicalein, and baicalin were evaluated for anti-inflammatory action and the activatory effect on gingival fibroblasts. In LPS-induced production of IL-1β, three flavonoids at 1 µg/ml expressed a significant (>50%) inhibitory effect, similar to that of prednisolone. Moreover, the flavonoids inhibited IL-1β-induced synthesis of PGE2 and LTB4 considerably, although the effect of wogonin on LTB4 synthesis was marginal. In addition, three flavonoids exerted a moderate inhibition (33 - 36%) of collagenolytic activity, comparable to 40% inhibition by tetracycline. Meanwhile, the cellular activity of fibroblasts was augmented remarkably (40%) by baicalein (2) and slightly by baicalin (3) or wogonin (1). Consistent with the cellular activation, flavonoids enhanced the synthesis of both collagen and total protein in fibroblasts, in contrast to growth factors which increased only the synthesis of total protein. Although the effects of the methanolic extract resembled those of the flavonoids, the extract expressed a preferential effect on the synthesis of collagen and total protein.

    >