Endoscopy 2015; 47(S 01): E262-E263
DOI: 10.1055/s-0034-1391952
Cases and Techniques Library (CTL)
© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic ultrasound-guided therapy of a gastrointestinal stromal tumor (GIST)

Eduardo Valdivielso Cortázar
Digestive Department, Complejo Hospitalario de Navarra, Pamplona, Spain
,
Ignacio Fernández-Urién
Digestive Department, Complejo Hospitalario de Navarra, Pamplona, Spain
,
Juan José Vila Costas
Digestive Department, Complejo Hospitalario de Navarra, Pamplona, Spain
,
Francisco Javier Jiménez Pérez
Digestive Department, Complejo Hospitalario de Navarra, Pamplona, Spain
› Author Affiliations
Further Information

Publication History

Publication Date:
22 June 2015 (online)

A 90-year-old man was admitted to our hospital because of recurrent upper gastrointestinal bleeding due to a 5-cm gastrointestinal stromal tumor (GIST) in the lesser curve of the stomach ([Fig. 1]). After conventional endoscopic sclerotherapy failed to achieve a response, and because of the patient’s condition, it was decided to perform endoscopic ultrasound (EUS)-guided therapy.

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Fig. 1 Subepithelial lesion in a 90-year-old man undergoing endoscopic ultrasound-guided sclerotherapy for recurrent upper gastrointestinal bleeding shows no stigmata of bleeding.

The lesion was located at the lesser curve of the stomach; therefore, it was easily approached with the echoendoscope and punctured with a 20-gauge needle (Cook Ireland Ltd., Limerick, Ireland). This needle is specifically designed for celiac plexus neurolysis, and the multiple perforations at the tip allow better diffusion of the injected agent. The needle was placed in the middle of the lesion, and 1.5 mL of 99 % alcohol was injected ([Fig. 2]). The original plan had been to inject the alcohol first in the middle of the lesion and then in the distal and proximal areas to ensure adequate therapeutic coverage. However, because excellent diffusion of the alcohol was observed along the entire lesion during the first injection, it was not placed in other areas.

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Fig. 2 Endoscopic ultrasound-guided sclerotherapy with the injection of alcohol into the middle of the lesion (arrow).

During a second-look endoscopy 1 week later, partial necrosis of the lesion was noted ([Fig. 3]), and 3 months later, the tumor had practically disappeared ([Fig. 4]). Only a slight, isolated thickening of the gastric folds was seen. During a follow-up of 3 years, no episodes of rebleeding occurred.

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Fig. 3 Partial necrosis of the lesion at 1 week after treatment.
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Fig. 4 Disappearance of the treated lesion after 3 months.

Although the first-line treatment of GISTs is surgery, EUS-guided therapy can be considered because it has been demonstrated to be feasible and effective in selected cases. Complications resulting from the injection of alcohol in luminal and extraluminal gastrointestinal lesions, such as ulcerations in gastric lesions [1] and intratumoral hemorrhage and pancreatitis in hepatic and pancreatic lesions, have been described [2] [3] [4] [5]. However, all reported cases were mild and responded to conservative therapy.

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  • References

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