Clinical–alimentary tractThe Effect of Acute Psychologic Stress on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis
Section snippets
Patients and Controls
Twenty-five patients with quiescent UC (13 males; median age, 44 years [range, 28–64]; 32% distal, 20% left-sided, 48% total UC; 76% on 5-ASA, 12% on thiopurines, 4% on methotrexate, none on steroids; median disease duration 10 years [range, 3–31]) and 11 healthy volunteers (HV) (4 males; median age, 27 years [range, 23–56]) underwent the stress protocol. Ten patients with quiescent UC (3 males; median age, 52 years [range, 23–65]; 40% distal, 30% left-sided, 30% total UC; 90% on 5-ASA, 10% on
Autonomic Response to Stress Protocol
The mean of the 3 pulse rate readings measured during the stress protocol was increased compared with pretest values by 7 bpm (median) in patients with quiescent UC (P < .0001) and by 11 bpm in HV (P = .02). Thirty minutes after the end of the stress protocol, the mean pulse rate had returned to baseline in both groups (Table 1).
Mean systolic blood pressure increased during the stress protocol by a median of 12 mm Hg in patients with UC (P < .0001) and 9 mm Hg in HV (P = .03). In patients with
Discussion
In this study, experimental stress caused increases in a range of inflammatory variables, each of which could contribute to stress-induced relapses in UC.
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Supported by the Broad Medical Research Foundation (BMRF).