Issue 4, 2005

Antibiotic resistance: multidrug efflux proteins, a common transport mechanism?

Abstract

Covering: up to the end of 2004

The phenomenon of antibiotic resistance in micro-organisms and higher animals including humans, together with the various forms this resistance can take, is discussed. The focus of the review is the resistance, by efflux, to several structurally unrelated antibiotics by multidrug transport proteins. Putative and necessarily differing mechanisms, often supported convincingly by X-ray structural information, are discussed. The review covers the period up to the end of 2004 and contains 75 references.

Graphical abstract: Antibiotic resistance: multidrug efflux proteins, a common transport mechanism?

Article information

Article type
Review Article
Submitted
15 Jun 2005
First published
21 Jul 2005

Nat. Prod. Rep., 2005,22, 439-451

Antibiotic resistance: multidrug efflux proteins, a common transport mechanism?

K. P. Langton, P. J. F. Henderson and R. B. Herbert, Nat. Prod. Rep., 2005, 22, 439 DOI: 10.1039/B413734P

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