Abstract
The use of high-dose chemotherapy for metastatic breast cancer has been an area of recent interest and the role of such treatment in the management of metastatic breast cancer is still to be defined. Multiple studies have suggested that such treatment can be given with minimal morbidity and mortality. We describe two cases of life-threatening interstitial pneumonitis, following high-dose chemotherapy (HDT) with cyclophosphamide, thiotepa and docetaxel with stem cell rescue given for metastatic breast cancer. The available relevant literature is reviewed. Bone Marrow Transplantation (2001) 27, 559–563.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ettinger NA, Trulock EP . Pulmonary considerations of organ transplantation Am Rev Respir Dis 1991 144: 213–223
Cao TM, Negrin RS, Stocker-Goldstein KE et al. Pulmonary toxicity syndrome in breast cancer patients undergoing BCNU-containing high-dose chemotherapy and autologous hematopoietic cell transplantation Biol Blood Marrow Transplant 2000 6: 387–394
Kantrow SP, Hackman RC, Boeckh M et al. Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation Transplantation 1997 63: 1079–1086
Peters W, Rosner G, Vredenburgh J et al. A prospective, randomised comparison of two doses of combination alkylating agents as consolidation after CAF in high-risk primary breast cancer involving ten or more axillary lymph nodes: preliminary results of CALGB 9082/SWOG 9114/NCIC MA-13 Proc Am Soc Clin Oncol 1999 18: 1a (Abstr.)
Prince HM, Rischin D, Toner GC et al. Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study Bone Marrow Transplant 2000 26: 955–961
Prince HM, Toner GC, Seymour JF et al. Docetaxel effectively mobilizes peripheral blood CD34+ cells Bone Marrow Transplant 2000 26: 483–487
Cuguilliere A, Berard H, N'Guyen G et al. Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature Rev Pneumol Clin 1999 55: 100–104
Merad M, Le Cesne A, Baldeyrou et al. Docetaxel and interstitial pulmonary injury Ann Oncol 1997 8: 191–194
Lin AY, Flowers CM, Chen MC et al. Interstitial pneumonitis as a late complication of high dose therapy with cyclophosphamide/thiotepa and peripheral blood progenitor cells for carcinoma of the breast Clin Oncol (R Coll Radiol) 1999 10: 65
Mahendra P, Hood IM, Lee MA et al. Interstitial pneumonitis as a late complication of high dose therapy with cyclophosphamide/thiotepa and peripheral blood progenitor cells for carcinoma of the breast Clin Oncol (R Coll Radiol) 1996 8: 198–200
Holland DK, Dix SP, Geller RB et al. Minimal toxicity and mortality in high-risk breast cancer patients receiving high-dose cyclophosphamide, thiotepa and carboplatin and autologous marrow/stem-cell transplantation and comprehensivesupportive care J Clin Oncol 1996 14: 1156–1164
Foncuberta MC, Dictor M, Salum G et al. Pulmonary toxicity of high-dose thiotepa containing regimens in breast cancer patients undergoing autologous haematopoietic transplant Blood 1996 88: (Suppl. 1) 3755 (Abstr.)
Prince HM, Millward MJ; Rischin D et al. Repetitive high-dose therapy with ifosfamide, thiotepa and paclitaxel withperipheral blood progenitor cell and filgrastim support formetastatic and locally advanced breast cancer: results of a phase I study Ann Oncol 1999 10: 479–481
Adler H, Beland JL, Kozlow W et al. A role for transforming growth factor B1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type I infecction Blood 1998 7: 2581–2589
Anscher MS, Peters WP, Reisenbichler H et al. Transforming growth factor B as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer New Engl J Med 1993 328: 1592–1598
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mileshkin, L., Prince, H., Rischin, D. et al. Severe interstitial pneumonitis following high-dose cyclophosphamide, thiotepa and docetaxel: two case reports and a review of the literature. Bone Marrow Transplant 27, 559–563 (2001). https://doi.org/10.1038/sj.bmt.1702803
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702803
Keywords
This article is cited by
-
Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review
Journal of Medical Case Reports (2012)
-
Seltene Komplikation einer Vaskulitistherapie
Der Nephrologe (2010)