Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation

Bone Marrow Transplantation volume 23, pages 739–741 (1999)Cite this article

Abstract

We report the case of a 32-year-old patient with ALL who developed autoimmune thrombocytopenia 2 months following allogeneic bone marrow transplantation. An IgM autoantibody against the platelet glycoprotein Ib/IX complex was observed. Treatment with high-dose steroids and intravenous immunoglobulin G failed to produce any benefit and the thrombocytopenia led to fatal gastrointestinal haemorrhage. The possible factors contributing to post-allograft thrombocytopenia and potential management strategies are discussed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Author notes

  1. P D Kottaridis: Correspondence: Dr P Kottaridis, Department of Clinical Haematology, University College London Hospitals, 3rd Floor, Grafton Way, London WC1E 6AU, UK

Authors and Affiliations

  1. Department of Haematology, University College London Hospitals, UK

    P D Kottaridis, A R Perry, A J Peniket, A H Goldstone & S Mackinnon

  2. National Blood Service East Anglia, Cambridge, UK

    H Rees, G Smith, S F Garner & W H Ouwehand

  3. Department of Haematology, University of Cambridge, UK

    W H Ouwehand

  4. National Institute for Biological Standards and Control, Potters Bar, UK

    W H Ouwehand

Authors
  1. P D Kottaridis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H Rees
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S F Garner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A R Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A J Peniket
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A H Goldstone
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S Mackinnon
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. W H Ouwehand
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kottaridis, P., Rees, H., Smith, G. et al. A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation. Bone Marrow Transplant 23, 739–741 (1999). https://doi.org/10.1038/sj.bmt.1701651

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1701651

Keywords

This article is cited by

Search

Advanced search

Quick links