The transcriptional network downstream of the insulin receptor is incompletely understood, but recent data identify a new player. Foxa2—a forkhead transcription factor—controls hepatic lipid metabolism in fasting and type 2 diabetes, improving insulin resistance in peripheral tissues.
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References
Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J.M. & Stoffel, M. Nature 432, 1027–1032 (2004).
McGarry, J.D. Diabetes 51, 7–18 (2002).
Casteels, K. & Mathieu, C. Rev. Endocr. Metab. Disord. 4, 159–166 (2003).
Biddinger, S.B. & Kahn, C.R. Annu. Rev. Physiol. (10.1146/annurev.physiol.68.040104.124723).
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Puigserver, P., Rodgers, J. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med 12, 38–39 (2006). https://doi.org/10.1038/nm0106-38
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DOI: https://doi.org/10.1038/nm0106-38
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