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Foxa2, a novel transcriptional regulator of insulin sensitivity

The transcriptional network downstream of the insulin receptor is incompletely understood, but recent data identify a new player. Foxa2—a forkhead transcription factor—controls hepatic lipid metabolism in fasting and type 2 diabetes, improving insulin resistance in peripheral tissues.

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Figure 1: Insulin regulates glucose and lipid metabolism through forkhead transcription factors.

Simon Fenwick

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Puigserver, P., Rodgers, J. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med 12, 38–39 (2006). https://doi.org/10.1038/nm0106-38

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