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Chromosome aberrations in solid tumors

Nature Genetics volume 34, pages 369–376 (2003)Cite this article

Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

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Figure 1: Schematic illustration of mechanisms by which chromosomal aberrations arise plus a summary of the ability of commonly applied technologies to detect the aberrations.
Figure 2: Schematic representation of receptor tyrosine kinase–mediated signaling.
Figure 3: Schematic illustration of chromosomal evolution in human solid tumor progression.

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Acknowledgements

This work was supported by the United States Public Health Service and the Avon Foundation.

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Authors and Affiliations

  1. Cancer Research Institute, University of California San Francisco, San Francisco, 94143-0808, California, USA

    Donna G Albertson, Colin Collins & Frank McCormick

  2. Department of Laboratory Medicine, University of California San Francisco, San Francisco, 94143-0808, California, USA

    Donna G Albertson, Colin Collins & Joe W Gray

  3. Department of Microbiology and Immunology, University of California San Francisco, San Francisco, 94143-0808, California, USA

    Frank McCormick

  4. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA

    Joe W Gray

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  1. Donna G Albertson
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Correspondence to Donna G Albertson or Joe W Gray.

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Albertson, D., Collins, C., McCormick, F. et al. Chromosome aberrations in solid tumors. Nat Genet 34, 369–376 (2003). https://doi.org/10.1038/ng1215

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