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The NOD mouse model of type 1 diabetes: As good as it gets?

Nature Medicine volume 5, pages 601–604 (1999)Cite this article

Abstract

Of the two well-known rodent models of human type 1 diabetes (the non-obese diabetic mouse and the BioBreeding rat) the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both strengths and weaknesses.

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Figure 1: Insulitis in humans and NOD mouse pancreas.

References

  1. Leiter, E.H. & Atkinson, M.A. NOD mice and related strains: Research applications in diabetes, AIDS, cancer and other diseases in Medical Intelligence Unit (R.G. Landes, Austin, 1998 ).

    Google Scholar 

  2. Delovitch, T.L. & Singh, B. The nonobese diabetic mouse as a model of autoimmune diabetes - immune dysregulation gets the NOD. Immunity 7, 727–738 (1997).

    Article  CAS  Google Scholar 

  3. Rabinovich, A. An update of cytokines in the pathogenesis of insulin dependent diabetes mellitus . Diabetes Metab. Rev. 14, 129– 151 (1998).

    Article  Google Scholar 

  4. Takahashi, K., Honeyman, M.C. & Harrison, L.C. Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin dependent diabetes. J. Immunol. 161, 2629–2635 (1998).

    CAS  PubMed  Google Scholar 

  5. Ellerman, K.E., Richards, C.A., Guberski, D.L., Shek, W.R. & Like, A.A. Kilham rat virus triggers T-cell-dependent autoimmune diabetes in multiple strains of rats. Diabetes 45, 557–562 (1996).

    Article  CAS  Google Scholar 

  6. Komeda, K. et al. Establishment of 2 substrains, diabetes-prone and nondiabetic, from Long-Evans Tokushima-Lean (LETL) rats. J. Endocrinol. 45, 737–744 (1998).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Florida College of Medicine, Gainesville, 32610, Florida, USA

    Mark A. Atkinson

  2. The Jackson Laboratory, Bar Harbor, Maine , 04609, USA

    Edward H. Leiter

Authors
  1. Mark A. Atkinson
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  2. Edward H. Leiter
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Atkinson, M., Leiter, E. The NOD mouse model of type 1 diabetes: As good as it gets?. Nat Med 5, 601–604 (1999). https://doi.org/10.1038/9442

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