Abstract
IT is well known that adipocytes with specific cell-membrane insulin receptors respond to insulin by increasing glucose uptake, oxidation and lipogenesis in the presence of glucose1–4. Maintenance of adipocyte insulin sensitivity during a state of relative muscle cell insulin resistance has been considered a possible mechanism for obesity in diabetes mellitus5. I now report that a distinct cell phenotype resists insulin but accumulates lipid in response to corticosteroid. Furthermore, corti-costeroid-induced lipogenesis is significantly greater in marrow preadipocytes of mutant diabetic-obese mice.
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GREENBERGER, J. Sensitivity of corticosteroid-dependent insulin-resistant lipogenesis in marrow preadipocytes of obese-diabetic (db/db) mice. Nature 275, 752–754 (1978). https://doi.org/10.1038/275752a0
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DOI: https://doi.org/10.1038/275752a0
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