Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects

Nature volume 191, pages 1114–1115 (1961)Cite this article

Abstract

THE inhibitory action of guinea pig serum on the cells of three transplantable mouse and rat lymphomas in vivo was described some years ago in papers from this Laboratory1,2. In a continuation of this work, evidence has now been found that the L-asparaginase activity of guinea pig serum is responsible for the antilymphoma effect. The evidence has been obtained in two ways: first, by a study of the induction of resistance to guinea pig serum by 6C3HED cells grown in tissue culture; and secondly, by a direct comparison of L-asparaginase activity in various preparations of guinea pig serum with their tumour inhibitory properties.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kidd, John G., J. Exp. Med., 98, 565 (1953).

    Article  CAS  Google Scholar 

  2. Kidd, John G., J. Exp. Med., 98, 583 (1953).

    Article  CAS  Google Scholar 

  3. Eagle, H. J., J. Exp. Med., 102, 595 (1955).

    Article  CAS  Google Scholar 

  4. Kidd, John G., J. Exp. Med., 108, 665 (1958).

    Article  CAS  Google Scholar 

  5. Clementi, A., Arch. Internat. Physiol., 19, 369 (1922).

    CAS  Google Scholar 

  6. Kunkel, H. G., and Slater, R. J., Proc. Soc. Exp. Biol. and Med., 80, 42 (1952).

    Article  CAS  Google Scholar 

  7. Ainis, H., Kurtz, H. M., Kramer, P. I., Weimer, H. E., Ryan, R. M., and Jameson, E., Cancer Res., 18, 1309 (1958).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, 21

    J. D. BROOME

Authors
  1. J. D. BROOME
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BROOME, J. Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects. Nature 191, 1114–1115 (1961). https://doi.org/10.1038/1911114a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1911114a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing