Journal of Otology

Journal of Otology

Volume 4, Issue 1, June 2009, Pages 34-43
Journal of Otology

Review
Permeability of round window membrane and its role for drug delivery: our own findings and literature review

https://doi.org/10.1016/S1672-2930(09)50006-2Get rights and content
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Abstract

We investigated the pharmacokinetics of caroverine in the perilymph, cerebrospinal fluid and plasma after systemic and local administrations in guinea pigs by using high-performance liquid chromatography. Auditory brainstem responses were measured to evaluate auditory functional effect. The results showed that local application was a both safe and efficient method. We further reviewed literature and pinpointed that the round window is effectively local drug delivery means for future inner ear treatment.

Keywords

Caroverine
glutamate receptor antagonist
antioxidant
pharmacokinetics
round window membrane
noise-induced hearing loss

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