Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and maxillofacial surgeryOnline only articleHistologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig
Section snippets
Implant materials
The Biocement D (Calcibon; Biomet Merck Biomaterials, Darmstadt, Germany) used in this study is a hydraulic fast-setting calcium phosphate bone cement. The cement precursor powder consists of tricalcium phosphate (TCP; Ca3(PO4)2), anhydrous dicalcium phosphate (DCPA; CaHPO4), and small amounts of calcium carbonate (CaCO3). After mixing the cement precursor with a defined amount of disodium hydrogen phosphate solution (Na2HPO4 aq, 4% w/w), it is transformed into calcium-deficient carbonated
Results
Following application at operation, the collagen cement composite could be manually molded for about 6-8 min. The material displayed good cohesion and had a high subjective stability after primary setting. It is not necessary for the implant substance to be kept dry during the hardening of the cement. Precise adaptation to the edges of the defect zone was possible (Fig. 2).
After the operation, 1 animal developed transient wound healing complications and received antibiotic treatment and
Discussion
The aim of the present study was to verify bone healing and remodeling of a bone replacement substance, based on calcium phosphate bone cement (Calcibon) modified with collagen type I.
Based on the results, we conclude that the applied hydroxyapatite-collagen cement is resorbable under in vivo conditions and shows good biocompatibility. Resorption can be seen as the combination of cellular macrophage activity and physiologic solubility.
This study confirms the suitability of the material as a
References (18)
- et al.
Long-term bone ingrowth and residual microhardness of porous block hydroxyapatite implants in humans
J Oral Maxillofac Surg
(1998) - et al.
Influence of osteocalcin and collagen I on the mechanical and biological properties of Biocement
Biomol Eng
(2002) The diagnostic value of the new method for the study of undecalcified bones and teeth with attached soft tissue (Sage-Schliff [sawing and grinding] technique)
Pathol Res Pract
(1985)- et al.
Growth and differentiation of human bone marrow osteoprogenitors on novel calcium phosphate cements
Biomaterials
(1998) - et al.
Preliminary evaluation of hydroxyapatite cement as an augmentation device in the edentulous atrophic canine mandible
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1998) - et al.
Porous root replacements: reactions of the surrounding tissues
J Dent
(1986) - et al.
[Integration properties of bone substitute materials. Experimental studies on animals]
Orthopade
(1998) - et al.
Osteogenesis in cranial defects: reassessment of the concept of critical size and the expression of TGF-beta isoforms
Plast Reconstr Surg
(2000) [Problems at the donor site in autologous bone transplantation]
Unfallchirurg
(1986)
Cited by (31)
Characterization of the osseointegration of Algipore and Algipore modified with mineralized collagen type i
2012, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :Several in vivo studies showed positive results for the combination of hydroxyapatite and collagen. In combination with nanocrystalline hydroxyapatite cements, positive results for collagen I could be demonstrated in the mandible of minipigs.16 Rammelt et al.18 observed a significantly increased bone implant contact after 28 days in rat tibiae using a nanocrystalline hydroxyapatite collagen I cement.
Miniature pigs as an animal model for implant research: bone regeneration in critical-size defects
2009, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and EndodontologyRegeneration of alveolar bone defects in the experimental pig model: A systematic review and meta-analysis
2024, Clinical Oral Implants ResearchCalcium orthophosphate (CaPO<inf>4</inf>) biocomposites with natural and synthetic polymers
2023, Biocomposites: Advances in Research and Applications
Biomet Biomaterials, Darmstadt, Germany, supplied the cement powder.