Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and Maxillofacial PathologyClinical and radiological features of central giant-cell lesions of the jaw
Section snippets
Material and methods
We reviewed all histologically confirmed giant-cell lesions in The Netherlands from 1990 to 1995 through PALGA (Pathologisch Anatomisch Landelijk Geautomatiseerd Archief). PALGA is an automated registration system with 100% coverage of all histology diagnoses in The Netherlands.
The data were retrieved from the records of the patients with CGCG who we screened for our earlier paper.20 The data were evaluated in 2002, so that sufficient time had elapsed to reliably evaluate the clinical course of
Results
From 1990 to 1995, 124 patients with giant-cell lesions were recorded, of whom 24 patients exhibited extra osseous or peripheral lesions. In 4 patients hyperparathyroidism was found and in 5 patients cherubism or a concomitant syndrome was diagnosed. This resulted in 91 patients with CGCG. In 8 patients the CGCG was a recurrence of a lesion from an earlier period, so that 83 patients with new CGCGs were diagnosed over the period from 1990 to 1995 (male/female = 36/47). The mean age at the time of
Discussion
Until recently, information on the epidemiological features of CGCGs was based on clustered groups of patients, and as such provided no indication of the occurrence of CGCGs in a general population. In a previous paper on epidemiological findings of CGCG in The Netherlands,20 we found an incidence of 0.00011% in the Dutch population. In the absence of similar data from other general populations, we assume that this figure approximately represents the incidence of CGCG elsewhere in the world. In
Conclusion
This 5-year population-based study includes all patients with central giant-cell lesions of the jaw in The Netherlands.
In a general population, large and aggressive CGCGs are less common than suggested by the literature. Multiple lesions in patients with CGCG, however, occur more frequently than previously assumed. There was also a strong association between multiple lesions and disorders such as neurofibromatosis type 1 and Noonan syndrome.
Evaluation of the surgical therapy in the population
References (34)
Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones
Oral Surg
(1953)- et al.
The gene for cherubism maps to chromosome 4p16.3
Am J Hum Genet
(1999) - et al.
The gene for cherubism maps of chromosome 4p16
Am J Hum Genet
(1999) Central giant cell granulomas of the jaws regress with calcitonin therapy
Br J Oral Maxillofac Surg
(1993)- et al.
Treatment of central giant cell granuloma of the jaw with calcitonin
Int J Oral Maxillofac Surg
(1999) - et al.
Calcitonin treatment for central giant cell granulomas of the mandible: report of two cases
J Oral Maxillofac Surg
(1999) - et al.
Rapid growth of giant cell granuloma in pregnancy treated with calcitonin
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2001) - et al.
Antiangiogenenic therapy with interferon alpha for giant cell lesions of the jaws
J Oral Maxillofac Surg
(2002) Calcitonin therapy for central giant cell granuloma
J Oral Maxillofac Surg
(2003)- et al.
Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases
J Oral Maxillofac Surg
(1988)
Central giant cell lesions of the mandible and maxilla: a clinicopathologic and cytometric study
Oral Surg Oral Med Oral Pathol
Central giant cell granuloma of the jaws: a clinico-radiological study
Clin Radiol
Central giant cell lesions of the jaws
Oral Surg Oral Med Oral Pathol
A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor
Oral Surg Oral Med Oral Pathol
Radiologic features of central giant cell granuloma of the jaws
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Synchronous central giant cell lesions of the jaws
J Oral Maxillofac Surg
Bilateral central giant cell granulomas in a patient with neurofibromatosis: report of a case and review of the literature
J Oral Maxillofac Surg
Cited by (156)
An expansile radiolucent lesion of the maxilla in an 11-year-old male
2024, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyA subpontine osteolytic lesion of the mandible
2023, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyMandibular radiolucency in an 11-year-old girl
2023, Journal of the American Dental AssociationCentral giant cell granuloma in a paediatric maxilla: surgical management and a novel gene translocation
2022, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCase reports: An aggressive central giant cell granuloma of the jaws in two pediatric patients
2021, Journal of Pediatric Surgery Case Reports