Cell Stem Cell
Volume 9, Issue 4, 4 October 2011, Pages 317-329
ArticleSox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
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Graphical Abstract
Highlights
► Stem cell factor Sox2 is expressed in multiple adult self-renewing epithelia ► Adult Sox2+ stem cells are derived from fetal Sox2+ progenitors ► Transplantation of Sox2+ testis cells restores spermatogenesis in infertile mice ► Ablation of adult Sox2+ cells disrupts tissue integrity and results in lethality
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Present address: Monash Immunology and Stem Cell Laboratories, Monash University, Wellington Road, Clayton, VC 3800 Melbourne, Australia
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Present address: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
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