Radiotherapy of NPCSmoking is a poor prognostic factor for male nasopharyngeal carcinoma treated with radiotherapy
Section snippets
Patient populations
This work had been approved by the ethics committees of Sun Yat-Sen University Cancer Center (SYSUCC). The medical records of 2820 patients newly diagnosed with NPC without distant metastasis in SYSUCC from November of 2000 to December of 2004 were reviewed. All patients received radical radiotherapy and completed the prescribed course of treatment. The exclusion criteria included: (1) lost follow-up within 5 years from diagnosis, (2) lack of the record of smoking habits. A total of 2450
Demographics
The baseline characteristics of the whole patients, male patients and matched-pair male patients are listed in Table 1. Gender and age proportion were significantly different in total patients and male patients with P < 0.001. No statistically different distribution existed in matched-pair patients. Due to most pathological types of the whole patients were undifferentiated non-keratinizing carcinoma (86.7%), we did not list pathological types in the baseline table. The KPS was mostly 90 scores
Discussion
Our study showed that smoking poorly impacts the prognosis of male NPC patients treated by radiotherapy (HR = 2.316, P < 0.001; matched-pair analysis). Quitting could not change the survival outcomes if the patient had smoked ever. Quantity analysis showed that, for male patients, high degree of SI group had a 1.225 fold hazard ratio of death risk compared with low degree of SI group (P = 0.016). Further analysis indicated that the impact of smoking quantity on prognosis was mainly caused by heavy
Conflicts of interest and informed consent
The authors have declared no conflicts of interest. Informed consent was obtained.
Acknowledgement
This work was supported by the Hi-Tech Research and Development Program of China (Grant number 2006AA02Z4B4).
References (31)
- et al.
Nasopharyngeal carcinoma
Ann Oncol
(2002) - et al.
Epidemiology of nasopharyngeal carcinoma
Semin Cancer Biol
(2002) - et al.
Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review
Semin Cancer Biol
(2012) - et al.
Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome
Int J Radiat Oncol Biol Phys
(2011) - et al.
Influence of smoking and alcohol drinking behaviors on treatment outcomes of patients with squamous cell carcinomas of the head and neck
Int J Radiat Oncol Biol Phys
(2009) - et al.
Effect of smoking on oxygen delivery and outcome in patients treated with radiotherapy for head and neck squamous cell carcinoma – a prospective study
Radiother Oncol
(2012) - et al.
FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial
Radiother Oncol
(2012) Nasopharyngeal carcinoma
Orphanet J Rare Dis
(2006)- et al.
The enigmatic epidemiology of nasopharyngeal carcinoma
Cancer Epidemiol Biomarkers Prev
(2006) - et al.
The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types
BMC Public Health
(2008)
Independent effect of EBV and cigarette smoking on nasopharyngeal carcinoma: a 20-year follow-up study on 9,622 males without family history in Taiwan
Cancer Epidemiol Biomarkers Prev
Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa
Br J Cancer
A prospective study of tobacco and alcohol use as risk factors for pharyngeal carcinomas in Singapore Chinese
Cancer
Pretreatment health behaviors predict survival among patients with head and neck squamous cell carcinoma
J Clin Oncol
Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer
N Engl J Med
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Impact of smoking on survival in nasopharyngeal carcinoma: A cohort study with 23,325 patients diagnosed from 1990 to 2016
2021, Radiotherapy and OncologyCitation Excerpt :Finally, as smoking patients suffer a higher risk of treatment failure, a higher frequency of follow-up can be used to detect tumor progression as soon as possible to perform early interventions. Compared to other studies, our study has several strengths [11–13]. First, we investigated a large cohort with more than 20,000 patients in over two decades, providing more reliable and convincing results.
Ten-year outcomes of a randomised trial for locoregionally advanced nasopharyngeal carcinoma: A single-institution experience from an endemic area
2015, European Journal of CancerCitation Excerpt :In addition to N-stage, age, gender and total radiotherapy doses, which are common prognostic factors in NPC [31], LDH, BMI and smoking are important baseline prognostic factors for tumour recurrence or distant metastasis. These findings are consistent with those presented in previous studies [13,14,32,33]. Currently, distant metastasis is the predominant pattern of failure in locoregionally advanced nasopharyngeal carcinoma [8].
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These authors contributed equally to this work.