Review ArticleRegenerative Endodontic Therapy: A Data Analysis of Clinical Protocols
Section snippets
Search Methodology and Study Selection
An electronic search was conducted using the PubMed database (www.ncbi.nlm.nih.gov) covering the period from January 1993 to the second week of May 2014. The following appropriate Medical Subject Heading (MeSH) terms for the electronic search were formed by using 12 relevant guide articles: ((((((“dental pulp”[MeSH Terms] OR (“dental”[All Fields] AND “pulp”[All Fields]) OR “dental pulp”[All Fields] OR “pulp”[All Fields]) AND revascularization[All Fields]) OR ((“dental pulp”[MeSH Terms] OR
Results
Three hundred eighty-two articles were found from the electronic search and another 3 articles from hand searching and the reference sections. Three hundred twenty-five articles were discarded according to the exclusion criteria of the study. Sixty relevant publications were finally included in this review (Table 1).
The methods, agents, and medicaments used in REPs are summarized in Table 2. The canal walls were not mechanically instrumented in 68% of the clinical articles. NaOCl was included
Discussion
The concept of regenerative endodontic therapy was introduced in the early 70s. Nygaard-Ostby and Hjortdal (66) ascertained the growth of new vascularized tissue into the empty apical portion of root canals after overinstrumentation and intracanal bleeding formation. The creation of a blood clot inside the root canal was defined by the researchers as a possible prognostic factor on the formation of new vital tissue (66). However, regenerative endodontic therapy was substantially initiated in
Acknowledgments
The authors deny any conflicts of interest related to this study.
References (86)
- et al.
Paradigm lost: a perspective on the design and interpretation of regenerative endodontic research
J Endod
(2014) - et al.
Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?
J Endod
(2004) - et al.
A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures
J Endod
(2009) - et al.
Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study
J Endod
(2012) - et al.
Regeneration potential of the young permanent tooth: what does the future hold?
J Endod
(2008) - et al.
Pulp revascularization of immature teeth with apical periodontitis: a clinical study
J Endod
(2009) - et al.
Levels of evidence for the outcome of regenerative endodontic therapy
J Endod
(2014) - et al.
Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift
J Endod
(2006) - et al.
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series
J Endod
(2008) - et al.
Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study
J Endod
(2008)
Regenerative treatment of an immature, traumatized tooth with apical periodontitis: report of a case
J Endod
Regenerative endodontic treatment for necrotic immature permanent teeth
J Endod
Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report
J Endod
Challenges in regenerative endodontics: a case series
J Endod
Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series
J Endod
Continued development of the root separated from the main root
J Endod
Revitalization of tooth with necrotic pulp and open apex by using platelet-rich plasma: a case report
J Endod
Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial
J Endod
Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study
J Endod
Drawbacks and unfavorable outcomes of regenerative endodontic treatments of necrotic immature teeth: a literature review and report of a case
J Endod
Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure
J Endod
Revitalization procedures in two traumatized incisors with different biological outcomes
J Endod
A clinical and histological report of a tooth with an open apex treated with regenerative endodontics using platelet-rich plasma
J Endod
Endodontic clinical management of a dens invaginatus case by using a unique treatment approach: a case report
J Endod
Regenerative endodontic treatment of permanent teeth after completion of root development: a report of 2 cases
J Endod
Is pulp regeneration necessary for root maturation?
J Endod
Histological findings of revascularized/revitalized immature permanent molar with apical periodontitis using platelet-rich plasma
J Endod
Clinical, radiographic, and histological observation of a human immature permanent tooth with chronic apical abscess after revitalization treatment
J Endod
Pulp revascularization of immature dens invaginatus with periapical periodontitis
J Endod
Regenerative endodontic treatment of an immature permanent tooth at an early stage of root development: a case report
J Endod
Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization
J Endod
Histologic and histobacteriologic observations of failed revascularization/revitalization therapy: a case report
J Endod
Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols
J Endod
Revascularization outcomes: a prospective analysis of 16 consecutive cases
J Endod
Traumatized immature teeth treated with 2 protocols of pulp revascularization
J Endod
Revascularization: a treatment for permanent teeth with necrotic pulp and incomplete root development
J Endod
The effect of sodium hypochlorite and chlorhexidine on cultured human periodontal ligament cells
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation
J Endod
Antimicrobial activity of 2.5% sodium hypochlorite and 0.2% chlorhexidine gluconate separately and combined, as endodontic irrigants
J Endod
The effect of passive ultrasonic activation of 2% chlorhexidine or 5.25% sodium hypochlorite irrigant on residual antimicrobial activity in root canals
J Endod
Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips
J Endod
Dentin conditioning codetermines cell fate in regenerative endodontics
J Endod
Direct effect of intracanal medicaments on survival of stem cells of the apical papilla
J Endod
Cited by (155)
Current Trends in Regenerative Endodontics: A Web-based Survey
2024, Journal of EndodonticsEffects of ethylenediaminetetraacetic acid on stem cells from the apical papilla: In vitro study
2023, Journal of Dental Sciences