Collective reviewSolid Pseudopapillary Tumors of the Pancreas: Review of 718 Patients Reported in English Literature
Section snippets
Methods
Since 1933, when the first article in the field of the pancreatic papillary neoplasms was reported by Lichtenstein,5 until December 2003 we found 210 articles that described 718 well-documented cases of pancreatic SPTs in the English literature. Each article was carefully studied and a database was created with all patients’ characteristics. The database included age, gender, symptoms, localization, size of the tumor, metastasis or invasions of adjacent tissues, treatment, and followup. Every
Results
It was interesting to find that 167 of 210 articles (79.5%) originated from the US, Europe, and Japan. Respectively, 582 patients came from those three regions, representing 81.1% of the total number of patients. Table 1 presents those cases that fulfill the criteria that qualify them as well-documented.
Among 690 patients (96.10%), 64 were men and 626 were women (9.78:1). Mean age of the 710 patients (98.89%) with available age data was 21.97 years (ranging from 2 to 85 years). Figure 1 shows
History
Four articles played a decisive roll in the history of SPTs. Lichtenstein,5 Franz,7 Klöppel,18 and WHO.19 At necropsy, 5 years after her initial presentation, a papillary cystadenocarcinoma in the tail of the pancreas was found, which had metastasized to the peritoneum, omentum, and liver. In 1959, Franz7 described three patients, two women and one man, and recognized the special characteristics of the tumor. Between 1960 and 1980, several authors8, 9, 10, 11, 12, 13, 14, 15, 16, 17 wrote
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Competing Interests Declared: None.