ReportCutaneous angiosarcoma: a case series with prognostic correlation☆
Section snippets
Materials and methods
In all, 47 cases of CA were retrieved from the files of 4 large departments of pathology located throughout the United States at institutions where the authors were affiliated. Inclusion criteria for the study included: (1) angiosarcoma arising within the dermis or subcutaneous fat; (2) initial epidemiologic data including age, location, sex, and clinical impression; (3) histologic glass slides for independent pathology review; and (4) confirmation of endothelial histogenesis by ultrastructural
Results
The clinicopathologic features of the 47 cases are summarized in Table I. The patients' age ranged from 59 to 92 years (mean: 75.1 years). The majority of the patients were men (76%). The most common anatomic location was the scalp (49%) followed by the cheek (19%). Of the cases, 95% were located on the head and neck. The most common initial clinical impression was angiosarcoma (38%), followed by lymphoma, primary carcinoma, and metastases in 10% of the cases. Other clinical diagnoses included
Discussion
The prognostic significance of histologic and clinical attributes in CA is reported herein. From this compilation of data, several important conclusions that may have meaningful prognostic and treatment implications emerge. Although these findings essentially support several previous studies, additional information, particularly as it relates to the histologic features of CA, may also have prognostic relevance.
Clinical attributes studied included patient age, sex, and anatomic location. As has
References (27)
- et al.
Soft tissue sarcomas of the head and neck in adults
Am J Surg
(1990) - et al.
Angiosarcoma of the head and neck
Am J Surg
(1994) - et al.
The surgical treatment and outcome of soft tissue sarcoma
Arch Surg
(1981) - et al.
Soft tissue sarcomascurrent trends in diagnosis and management
Curr Probl Cancer
(1989) - Bardwil J, Mocega E, Butler J, et al. Angiosarcoma of the head and neck region. Am J Surg...
- et al.
Angiosarcoma
Arch Dermatol
(1969) - et al.
Hemangioendothelioma of the skin
Arch Dermatol Syph
(1945) - et al.
Angiosarcoma of the face and scalp, prognosis, and treatment
J Dermatol Surg Oncol
(1991) Angiosarcomas of the skin
Semin Diagn Pathol
(1987)- Donnell R, Rosen P, Lieberman P, et al. Angiosarcoma and other vascular tumors of the breast: pathologic analysis as a...
Soft tissue sarcomas
Ann Surg
Cutaneous angiosarcoma
Cancer
Angiosarcoma of the face and scalp
Int J Dermatol
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Funding sources: None.
Conflicts of interest: None identified.