Immediate breast reconstruction using porcine acellular dermal matrix (Strattice™): Long-term outcomes and complications
Section snippets
Patients and methods
Patients who underwent immediate single-stage or two-stage implant-based breast reconstruction with the assistance of Strattice were included in this study. Patients who had undergone previous reconstructions and those who had implant-based flap procedures were excluded from the study. Breast reconstructions were performed between April 2008 and May 2009 in the authors' practice allowing for an adequate follow-up time period.
Strattice-assisted breast reconstruction was performed in the fashion
Results
A total of 54 patients met the inclusion criteria and were evaluated in this study. Approximately three-quarters of the patients had bilateral mastectomy (Table 1). Of the 105 reconstructions, 77% were prophylactic and 23% were oncologic. Six oncologic breasts were irradiated and 4 oncologic patients received chemotherapy. Almost all of the reconstructions were single stage, except for 4 which were two-staged. The mean implant volume of single-stage reconstructions was 444.1 ± 91.8 cc (range:
Discussion
Strattice is a porcine-derived acellular dermal matrix developed using the same principles as human ADM, AlloDerm® (LifeCell Corp., Branchburg, NJ). Additionally, it is processed to remove the galactose-α-(1,3)-galactose terminal disaccharide epitopes, believed to play a major role in xenogenic rejection response.13 Similar to human ADM, Strattice has been shown to revascularize, recellularize, remodel, and integrate into host tissue with no evidence of encapsulation, resorption, or
Funding
No funds were received or utilized for this research.
Conflict of interest
C Andrew Salzberg, MD, is a consultant for LifeCell Corporation. All other authors have no disclosure.
Acknowledgment
The authors like to thank LifeCell Corporation for editorial assistance.
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