Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1842, Issue 7, July 2014, Pages 971-980
ReviewEpigenetic modifications in colorectal cancer: Molecular insights and therapeutic challenges
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Abbreviations
5-FU
fluorouracil
A
acetyl-groups
ALDH1
aldehyde dehydrogenase-1
AP-1
activator protein 1
APC
adenomatous polyposis coli
ASO
anti-sense oligonucleotides
Bmi1
B lymphoma Mo-MLV insertion region 1 homolog
BMP
bone morphogenetic protein
CSC
cancer stem cell
CBP
CREB-binding protein
CDH1
cadherin-1
CDKN2A
cyclin-dependent kinase inhibitor 2A
CDX1
caudal type homeobox-1
CGI
CpG islands
CIMP
CpG island methylator phenotype
CIN
chromosomal instability
CpG
cytosine guanine
CRC
colorectal cancer
DNMT
DNA methyltransferase
DNMTi
DNMT inhibitor
EGCG
epigallocatechin 3-gallate
ERK
extracellular signal-regulated kinase
EZH2
histone methyltransferase enhancer of Zeste 2
FDA
Food and Drug Administration
H
histone
HAT
histone acetyltransferases
HDAC
histone deacetylase
HDACi
HDAC inhibitor
HDMT
histone demethylases
HIF
hypoxia inducible factor
HMT
histone methyltransferase
HOTAIR
hox transcript antisense intergenic RNA
IGF2
insulin-like growth factor-2
K
lysine residue
KLF4
kruppel-like factor 4
linc
long intergenic non-coding
LINE
long interspersed nuclear element
LOI
loss of imprinting
me
methylation
LRES
long range epigenetic silencing
LSD1
lysine specific demethylase 1
me
methylation
MGMT
O-6-methylguanine-DNA methyltransferase
MLL4
mixed lineage leukemia-4
miRNA/miR
microRNA
MSI
microsatellite instability
MTD
maximum tolerated dose
NRF1
nuclear respiratory factor 1
NuRD
nucleosome remodeling and histone deacetylase
PCAF
(CBP)/p300 associated factor
PFS
progression-free survival
PI3K
phosphatidylinositide 3-kinase
PPARδ
peroxisome proliferator activated receptor δ
PRC
polycomb repressive complex
PTEN
phosphatase and tensin homolog
RUNX3
runt-related transcription factor 3
SAM
S-adenosyl-methionide
SEPT9
septin 9
VEGF
vascular endothelial growth factor
YY1
yin yang 1
ZEB
zinc finger E-box-binding homeobox
Keywords
Colorectal cancer
Epigenetics
Histone modification
DNA methylation
Therapy
Prognosis
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