Original articleGeneral thoracicPrognostic Factors and Family History for Survival of Esophageal Squamous Cell Carcinoma Patients After Surgery
Section snippets
Patients
From January 1995 to January 2007, 1,851 patients with carcinoma of the esophagus underwent esophagectomy in our institute. A total of 1,618 of these patients (87.9%) had squamous cell carcinoma and 233 patients (12.7%) had adenocarcinoma. It is recognized that squamous cell carcinoma and adenocarcinoma are two entirely different entities with different prognosis, so patients with adenocarcinoma were not in this study. Of 1,618 patients with ESCC, 26 died of postoperative complications. All
Survival and Univariate Analysis
The overall 3-year and 5-year postoperative survival rates were 43.7% and 26.2%, respectively, for all patients. For overall survival after esophagectomy, five prognostic factors were determined as significant by univariate p value: tumor size, p = 0.0027; lymphadenopathy, p less than 0.0001; grade of differentiation, p = 0.0137; stage of cancer, p less than 0.0001; and family history of esophageal cancer, p = 0.0457 (Table 1).
Results of Multivariate Analyses
Multivariate analyses of survival rates after esophagectomy were
Comment
The overall 3-year and 5-year survival rates were 43.7% and 26.2%, respectively, for patients with esophageal cancer after esophagectomy in this study, which were poorer than the results reported by Lee and colleagues [2]. We considered the reason was that the group of patients in our study had more cases of ESCC with stage III and stage IV. In our study, the overall 3-year and 5-year survival rates after resection were 82.8% and 58.6% for stage I, 51.2% and 34.1% for stage II, 38.1% and 20.7%
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