Coronary Artery DiseaseOutcome After ST Elevation Myocardial Infarction in Patients With Cancer Treated With Primary Percutaneous Coronary Intervention
Section snippets
Methods
The current Dutch registry prospectively included patients with STEMI treated in 3 tertiary centers in the Netherlands. The design of this registry has been described previously.7 In short, all consecutive patients undergoing primary PCI for STEMI from January 2006 to December 2009 were included. Patients without return of spontaneous circulation after out-of-hospital cardiac arrest were excluded, as well as patients permanently living outside the Netherlands to allow follow-up through
Results
During the inclusion period, 208 patients (6.0%) treated for STEMI had a history of cancer (hereafter referred to as patients with cancer) and 3,215 patients (92.3%) had no known history of cancer. Cancer history was uncertain in 60 patients (1.7%). Baseline characteristics are listed in Table 1. Patients with cancer were on average older, more often women, and more frequently had hypertension compared with patients without a history of cancer. Patients with cancer were less frequently smokers
Discussion
The present multicenter study evaluated the influence of cancer on the prognosis of patients with STEMI. Most notably, a cancer diagnosis in the 6 months before primary PCI was a strong predictor of early cardiac mortality. The adverse effect of cancer on prognosis after STEMI was partly explained by a high prevalence of anemia and the occurrence of cardiogenic shock, whereas outcome was independent of cancer treatment.
In the present population, patients with cancer were on average older and
Disclosures
The Department of Cardiology of Leiden University Medical Center received unrestricted research grants from Medtronic, Biotronik, Boston Scientific, Lantheus Medical Imaging, St. Jude Medical, Edwards Lifesciences, and GE Healthcare. All other authors have reported that they have no relationships relevant to the contents of this article to disclose.
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2021, American Journal of CardiologyCitation Excerpt :It should be also noted that in the US registry, only 27.1% of patients with active cancer underwent PCI, as often seen in clinical practice.8 In terms of long-term data, previous investigations have reported outcomes mostly up to 1 year following MI.6,7,21 Several previous studies including patients with cancer undergoing PCI for stable coronary artery disease and acute MI showed that the presence of cancer was associated with increased risks of both ischemic and bleeding events during a follow-up period for up to 5 years.22,23
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