ReviewThe aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 3. Immunocytochemistry of cytokeratin and other epithelial cell markers
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Epidermal growth factor (EGF) and transforming growth factor (TGF)
Epidermal growth factor (EGF), a potent mitogen, is a peptide growth hormone in human tissues which is important in the regulation of proliferation in normal and neoplastic cells. EGF activity is mediated by binding to its specific trans-membrane receptor EGFr. The latter is activated in its turn by the binding of another peptide, alpha-transforming growth factor (TGF-α). When EGF binds to the extracellular part of the receptor, it leads to the activation of a tyrosine kinase in its
Elafin
Elafin, also known as skin-derived antileukoproteinase inhibitor (SKALP), is an epithelial-specific, cationic elastase inhibitor that has been identified in cultured keratinocytes and its expression has been studied in OKC epithelium and compared with other jaw cysts, normal oral mucosa, dysplastic epithelia and some neoplastic lesions [23], [24]. Using polyclonal anti-SKALP rabbit antiserum, all examples of uninflamed OKC epithelia (n=10 sporadic and 10 syndrome related) showed strong, uniform
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