Survey
Insulin-like growth factor binding proteins and their role in controlling IGF actions

https://doi.org/10.1016/S1359-6101(96)00053-6Get rights and content

Abstract

The insulin-like growth factor binding proteins (IGFBPs) area family of six proteins that bind to insulin-like growth factor-I and -II with very high affinity. Because their affinity constants are between two- and 50-fold greater than the IGF-I receptor, they control the distribution of the IGFs among soluble IGFBPs in interstitial fluids, IGFBPs bound to cell surfaces or extracellular matrix (ECM) and cell surface receptors. Although there are six forms of insulin-like growth factor binding proteins, most interstitial fluids contain only three or four forms, and usually only one or two predominate. The proteins differ significantly in their biochemical characteristics, and this accounts for many of the differences that have been observed in their biological actions. Several different types of protease cleave these binding proteins. Proteolytic cleavage generally inactivates the binding proteins or reduces their ability to bind to IGF-I or -II substantially. Several cell types have been shown to secrete these proteases; therefore, the factors that regulate protease activity can control binding protein actions indirectly. Other post-translational modifications, such as glycosylation and phosphorylation, have been shown to alter IGF binding protein activity. While binding protein actions have been studied extensively in vitro, many of the in vivo activities of these proteins remain to be defined.

References (153)

  • JSM Demellow et al.

    Growth hormone dependent insulin-like growth factor binding protein both inhibits and potentiates IGF-I stimulated DNA synthesis in skin fibroblasts

    Biochem Biophys Res Commun

    (1988)
  • CA Conover et al.

    Acid-activated insulin-like growth factor binding protein-3 proteolysis in normal and transformed cells: role of cathepsin-D

    J Biol Chem

    (1994)
  • C Lalou et al.

    Evidence that proteolysis of insulin-like growth factor binding protein-3 occurs in the normal state outside of the bloodstream

    Regul Pept

    (1993)
  • JI Jones et al.

    Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1: Regulation of its affinity by phosphorylation of serine 101

    J Biol Chem

    (1993)
  • R.L. Hintz et al.

    Demonstration of specific plasma protein binding sites for somatomedin

    J Clin Endocr Metah

    (1977)
  • R.W. Furlanetto

    Somatomedin binding protein: Evidence for heterogenous subunit structure

    J Clin Endocr Metah

    (1980)
  • S.L.S. Drop et al.

    Isolation of a somatomedin-binding protein from preterm amniotic fluid

  • G Povoa et al.

    Isolation and characterization of a somatomedin binding protein from mid term human amniotic fluid

    Eur J Biochem

    (1984)
  • Y.L. Lee et al.

    Insulin like growth factor IGF binding protein complementary deoxyribonucleic acid from human Hep G2 hepatoma cells: predicted protein sequence suggests and IGF binding domain different from those of IGF-I and IGF-II receptors

    Molec Endocr

    (1988)
  • WI Wood et al.

    Cloning and expression of the GH dependent insulin like growth factor binding protein

    Molec Endocr

    (1988)
  • S Shimasaki et al.

    Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP in rat and human

    J Biol Chem

    (1991)
  • S.L.S. Drop et al.

    Immunoassay of a somatomedin-binding protein from human amniotic fluid: levels in fetal, neonatal, and adult sera

    J Clin Endocr Metab

    (1984)
  • RC Baxter et al.

    Radioimmunoassay of growth hormone dependent insulin-like growth factor binding protein in human plasma

    J Clin Invest

    (1986)
  • RC Baxter

    Physiological roles of the IGF binding proteins

  • R.R. Behringer et al.

    Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone deficient transgenic mice

    Endocrinology

    (1990)
  • RM Dechiara et al.

    A growth deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disruption

    Nature

    (1990)
  • J.P. Liu et al.

    Mice carrying small mutations of the genes encoding insulin like growth factor I (IGF-I) and type 1 IGF receptor (IGF/r)

    Cell

    (1993)
  • C Camacho-Hubner et al.

    Identification of the forms of insulin-like growth factor binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion

    J Biol Chem

    (1992)
  • P Hossenlopp et al.

    Heterogeneity of insulin-like growth factor binding proteins and relationships between structure and affinity. 2. Forms released by human and rat liver in culture

    Eur J Biochem

    (1987)
  • T.G. Unterman et al.

    Multihormonal regulation of insulin like growth factor binding protein-1 in rat H4 IIE hepatoma cells: the dominant role of insulin

    Endocrinology

    (1991)
  • GT Ooi et al.

    Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozoticin-diabetic rats

    Molec Endocr

    (1992)
  • A Swanichkul et al.

    Glucorticoids and insulin regulate expression of the human gene for insulin like growth factor binding protein-1 through proximal promoter elements

  • DS Strauss et al.

    Effect of fasting on insulin-like growth factor-I (IGF-I) and growth hormone receptor mRNA levels and IGF-1 gene transcription in rat liver

    Molec Endocr

    (1990)
  • M.L. Adamo et al.

    Insulin like growth factor I (IGF-I) and retinoic acid modulation of IGF binding proteins (IGFBPs)

  • T.L. Wood et al.

    The expression pattern of an insulin like growth factor (IGF) binding protein gene is distinct from IGF-II in mid gestation embryo

    Molec Endocr

    (1990)
  • T.L. Wood et al.

    Targeted gene disruption of the IGFBP-2 gene

    Growth Regul

    (1993)
  • M.L. Adamo et al.

    Regulation of insulin IGF-I and IGF-II gene expression

  • J.L. Walker et al.

    Effects of infusion of insulin-like growth factor-I in a child with growth hormone insensitivity syndrome

    N Engl J Med

    (1991)
  • A Takenada et al.

    Distribution of mRNAs of insulin-like growth factor binding proteins 1 and 3 between parenchymal and non-parenchymal cells in the liver

    J Biol Chem

    (1991)
  • B.A. Booth et al.

    Intrinsic bioactivity of insulin-like growth factor binding proteins from endothelial cells

    Endocrinology

    (1990)
  • MM Rechler et al.

    Insulin-like growth factors

  • RC Baxter et al.

    Structure of the MT 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity labeling

  • H-P Guler et al.

    Insulin-like growth factors I and II in healthy man

  • J Dai et al.

    Regulation of acid labile subunit of the rat serum insulin-like growth factor binding protein complex

    Endocrinology

    (1994)
  • SC Hodgkinson et al.

    Metabolic clearance of insulin-like growth factor-II in sheep

    J Endocr

    (1989)
  • J Dai et al.

    Regulation in vivo of acid labile subunit of the rat serum insulin like growth factor binding protein complex

    Endocrinology

    (1994)
  • J Zapf et al.

    Regulation of binding proteins for insulin-like growth factors in humans: Increased expression of IGF binding proteins during treatment of healthy adults and in patients with extrapancreatic tumor

    J Clin Invest

    (1990)
  • C Camacho-Hubner et al.

    Regulation of insulin-like growth factor binding proteins in transgenic mice with altered expression of growth hormone and IGF-I

    Endocrinology

    (1991)
  • W.H. Daughaday et al.

    Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet cell tumors

  • D.R. Clemmons et al.

    Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects

    J Clin Endocr Metab

    (1991)

    • Cited by (451)

    • IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis

      2023, European Journal of Pharmacology

    • Transcriptional response to cold and fasting acclimation in Onychostoma macrolepis during the overwintering stage

      2021, Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics

    • Integrating animal development: How hormones and metabolism regulate developmental transitions and brain formation

      2021, Developmental Biology

    • Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation

      2021, Journal of Dairy Science

    • The IGF–PAPP-A–Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer

      2024, International Journal of Molecular Sciences

    • The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma

      2024, Human Cell
    View all citing articles on Scopus
    View full text
    Copyright © 1997 Published by Elsevier Ltd.