Guided jaw-bone regeneration using an experimental rabbit model

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Abstract

The aims of this study were to evaluate the space-maintaining capacity of two biocompatible barrier materials and to assess the effect of barrier occlusiveness on the amount of regenerated bone. Defects were prepared in the edentulous area on both sides of the maxillas in 22 rabbits. The rabbits were divided into three groups. Gore-Tex® augmentation material (GTAM) (ePTFE)-barriers were placed to cover the experimental defects and compared with totally occlusive or perforated titanium foils and uncovered control defects respectively. After four weeks of healing, histological analyses and morphometrical measurements demonstrated that the amount of regenerated bone tissue was about the same underneath the collapsed GTAM-barriers as in the controls. The highest degree of regeneration was obtained in defects underneath the titanium foils, particularly if they were perforated, whether or not they were covered by GTAM-barriers. It was concluded that the space-maintaining properties of a barrier may be at least as important as barrier occlusiveness when regenerating bone defects.

References (24)

  • LundgrenAK et al.

    An experimental rabbit model for jaw-bone healing

    Int J Oral Maxillofac Surg

    (1997)
  • LundgrenD et al.

    Guided bone regeneration of cranial defects, using biodegradable barriers: an experimental pilot study in the rabbit

    J Cranio-MaxFac Surg

    (1992)
  • BeckerW et al.

    Guided tissue regeneration for implants placed into extraction sockets and for implant dehiscences: surgical techniques and case reports

    Int J Period Rest Dent

    (1990)
  • BeckerW et al.

    The use of e-PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets: a prospective multicenter study

    Int J Oral Maxillofac Impl

    (1994)
  • BuserD et al.

    Regeneration and enlargement of jaw bone using guided tissue regeneration

    Clin Oral Impl Res

    (1990)
  • BuserD et al.

    Localized ridge augmentation using guided bone regeneration. I. Surgical procedure in the maxilla

    Int J Period Rest Dent

    (1993)
  • DahlinC et al.

    Hcaling of bone defects by guided tissue regeneration

    Plast Reconstr Surg

    (1988)
  • DahlinC et al.

    Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits

    Int J Oral Maxillofac Impl

    (1989)
  • DahlinC et al.

    Healing of maxillary and mandibular bone defects using a membrane technique

    Scand J Plast Reconstr Hand Surg

    (1990)
  • DahlinC et al.

    Osteopromotion for cranioplasty. An experimental study in rats using a membrane technique

    J Neurosurg

    (1991)
  • DahlinC et al.

    Bone augmentation at fenestrated implants by an osteopromotive membrane technique. A controlled clinical study

    Clin Oral Impl Res

    (1991)
  • FribergB et al.

    Early failures in 4641 consecutively installed Brnemark implants. A study from stage one surgery to connection of complete prostheses

    Int J Oral Maxillofac Impl

    (1991)
  • Cited by (0)

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    Address: Dr Anna-Karin Lundgren Department of Biomaterials/ Handicap Research Institute for Surgical Sciences Göteborg University Medicinaregatan 8 S-413 90 Göteborg Sweden Tel: +46 31 773 29 50 Fax: +46 31 773 29 41

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