Scientific and clinical paperA new silver sulfadiazine water soluble gel
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Cited by (48)
Drug-delivery nanocarriers for skin wound-healing applications
2020, Wound Healing, Tissue Repair, and Regeneration in DiabetesDual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis
2019, Journal of Colloid and Interface ScienceUsing chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing
2017, Carbohydrate PolymersCitation Excerpt :In addition, SSD is mostly present in a 1% cream. This cream dosage form exhibits a number of general side effects, including their inability to maintain effective drug concentrations for a prolonged period at moist wound surfaces due to their short residence time, their messiness causing inconvenience to patients Dobaria, Badhan, & Mashru, 2009) and according to its manufacturers the SSD cream causes discoloration of the wound bed (Gear et al., 1997), which, after several applications, interferes with judging wound status. Also, it shows low silver release levels which affects the drug's efficacy as the antimicrobial efficiency of silver ions depends directly on its concentration, which should not drop under the limit value required for minimal inhibition.
Highly water-dispersible silver sulfadiazine decorated with polyvinyl pyrrolidone and its antibacterial activities
2016, Materials Science and Engineering CCitation Excerpt :The sulfa moiety could prevent bacterial folate absorption and subsequent DNA synthesis, whereas the silver that is released from SSD binds and disrupts the DNA structure, precluding bacterial DNA replication [4–6]. However, due to the intrinsic hydrophobic moiety and large size, the antibacterial performance of SSD is commonly discounted by its poor aqueous solubility [7,8]. In recent decades, nanotechnology has been used to enhance the solubility or dispersion of nanoparticles in media [9,10].
Optimal treatment of partial thickness burns in children: A systematic review
2014, BurnsCitation Excerpt :However at a later stage this may limit epithelial outgrowth by causing maceration [75,76]. This aspect could be solved by application of SSD in another material [73,74] or through shortening the period of usage by switching to an ointment based antiseptic [77] or another topical therapeutic [78]. Toxicity of silver component to keratinocytes: this is firmly established in in vitro experiments [79,80].
Silver sulfadiazine based cubosome hydrogels for topical treatment of burns: Development and in vitro/in vivo characterization
2014, European Journal of Pharmaceutics and Biopharmaceutics