Reactive oxygen species play an important role in iodoacetate-induced neurotoxicity in primary rat neuronal cultures and in differentiated PC12 cells
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Cited by (29)
Alpha tocopherol treatment reduces the expression of Nogo-A and NgR in rat brain after traumatic brain injury
2013, Journal of Surgical ResearchCitation Excerpt :Alpha-tocopherol, a member of the vitamin E family, reacts with free radicals, capturing unpaired electrons and effectively eliminating their ability to damage nerve tissue cells [23]. Vitamin E has been used in the treatment of TBI, with some success [24–26]. Raicević et al [27] administered oral vitamin E to patients in the acute phase of TBI and found that intracellular calcium overload was reduced, inhibiting neuronal mitochondria swelling.
Protection of PC12 cells from chemical ischemia induced oxidative stress by Fagonia arabica
2009, Food and Chemical ToxicologyDysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death
2009, Bioorganic and Medicinal ChemistryFlavonoids protect retinal ganglion cells from ischemia in vitro
2008, Experimental Eye ResearchCitation Excerpt :IAA has been used previously to induce ischemia in primary cultures of chick retinal cells (Ferreira et al., 1997; Rego et al., 1999a) as well as primary cortical neurons (Sperling et al., 2003) and cerebellar granule cells (Malcolm et al., 2000). The changes observed following IAA treatment of neural cells are very similar to changes which have been seen in animal models of retinal ischemia (Osborne et al., 2004) and include alterations in membrane potential (Reiner et al., 1990), breakdown of phospholipids (Taylor et al., 1996), loss of ATP (Sperling et al., 2003; Winkler et al., 2003) and an increase in reactive oxygen species (ROS) (Sperling et al., 2003; Taylor et al., 1996). As a test of this approach to identifying compounds that might protect RGCs from ischemia, we decided to focus on flavonoids, polyphenolic compounds widely distributed in fruits and vegetables (for reviews see Heim et al., 2002; Middleton et al., 2000; Ross and Kasum, 2002).