Cancer Letters

Cancer Letters

Volume 108, Issue 2, 29 November 1996, Pages 185-193
Cancer Letters

DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes

https://doi.org/10.1016/S0304-3835(96)04408-4Get rights and content

Abstract

We found that dimethyl-sulfoxide (DMSO) at concentrations of 2.5% induced apoptosis in SV40-immortalized human keratinocytes, while normal keratinocytes were arrested at the boundary of G1/S phase under the same conditions. DMSO-induced apoptosis in SV-40 immortalized keratinocytes was not associated with change in phospohrylated state of the retinoblastoma susceptibility gene. When SV40-immortalized cells were treated with 2.5% DMSO, dissociation of the complex was observed by immunoblotting of SV40 T antigen from immunoprecipitated p53 protein fraction.

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  • Cited by (0)

    1

    Present address: Genome Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263, Japan.

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